Genetic variant
rs9376090
rs9376090 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs9376090 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs9376090, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs9376090
- Position
- chr6:135090090
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean corpuscular hemoglobin | T | OR 0.19 | 4E-441 | PubMed |
| Mean corpuscular volume | C | OR 0.17 | 3E-369 | PubMed |
| Mean corpuscular volume | T | OR 0.18 | 1E-368 | PubMed |
| Red blood cell count | C | OR 0.13 | 4E-342 | PubMed |
| Red blood cell count | T | OR 0.15 | 1E-324 | PubMed |
| Red blood cell count | — | OR 0.14 | 2E-218 | PubMed |
| Mean corpuscular hemoglobin | C | β 0.077 | 2E-170 | PubMed |
| Hematocrit | C | β 0.08 | 7E-88 | PubMed |
| Hematocrit | C | β 0.06 | 2E-75 | PubMed |
| Hematocrit | T | β 0.071 | 1E-72 | PubMed |
| Glycated hemoglobin levels | T | β 0.025 | 2E-62 | PubMed |
| Mean corpuscular hemoglobin concentration | C | β 0.066 | 8E-60 | PubMed |
| Hemoglobin A1c levels | C | β 0.074 | 1E-51 | PubMed |
| Hemoglobin concentration | C | β 0.05 | 3E-34 | PubMed |
| Hemoglobin | C | β 0.038 | 2E-31 | PubMed |
| Mean corpuscular hemoglobin | C | OR 0.3 | 1E-29 | PubMed |
| ARG1/PKLR protein level ratio | — | β 0.089 | 4E-29 | PubMed |
| NSFL1C/RWDD1 protein level ratio | — | β 0.086 | 8E-29 | PubMed |
| Hemoglobin concentration | T | β 0.043 | 1E-28 | PubMed |
| PPCDC/RWDD1 protein level ratio | — | β 0.083 | 2E-26 | PubMed |
Sources
- dbSNP: rs9376090 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies