Genetic variant
rs884205
rs884205 is a single-letter difference in human DNA, on chromosome 18. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs884205 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs884205, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs884205
- Position
- chr18:62387624
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Alkaline phosphatase (UKB data field 30610) | C | β 0.036 | 3E-73 | PubMed |
| Serum alkaline phosphatase levels | C | β 0.04 | 3E-65 | PubMed |
| Serum alkaline phosphatase levels | A | OR 14.5 | 2E-47 | PubMed |
| Heel bone mineral density | A | β 0.028 | 6E-38 | PubMed |
| Heel bone mineral density | — | β 0.026 | 8E-30 | PubMed |
| Height | A | β 0.008 | 5E-28 | PubMed |
| Heel bone mineral density | — | — | 3E-27 | PubMed |
| SOST protein levels | C | β 0.055 | 1E-24 | PubMed |
| COL1A1 protein levels | C | β 0.06 | 2E-22 | PubMed |
| Tumor necrosis factor receptor superfamily member 11A levels | A | OR 0.29 | 2E-22 | PubMed |
| Lumbar spine bone mineral density | A | β 0.05 | 2E-17 | PubMed |
| C1QL2 protein levels | C | β 0.051 | 6E-17 | PubMed |
| CHAD protein levels | C | β 0.051 | 2E-16 | PubMed |
| TNFRSF11A protein levels | C | OR 0.47 | 6E-15 | PubMed |
| Tumor necrosis factor receptor superfamily member 11A levels (TNFRSF11A.8316.36.3) | C | OR 0.22 | 2E-14 | PubMed |
| Serum alkaline phosphatase levels | — | β 0.035 | 1E-13 | PubMed |
| Serum alkaline phosphatase levels | C | β 0.035 | 2E-13 | PubMed |
| Osteoporosis NOS (PheCode 743.11) | A | β 0.085 | 3E-13 | PubMed |
| Osteoporosis (PheCode 743.1) | A | β 0.084 | 3E-13 | PubMed |
| Total body bone mineral density | A | β 0.053 | 4E-13 | PubMed |
Sources
- dbSNP: rs884205 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies