RS8192675 Unknown gene
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What This Variant Does
"Impact of Genetic Polymorphisms of SLC2A2, SLC2A5, and KHK on Metabolic Phenotypes in Hypertensive Individuals"
Medication Interactions
Metformin efficacy
moderate
SLC2A2 — affects metformin response in type 2 diabetes
GWAS Studies (18)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Blood Glucose level in bendroflumethiazide treated hypertension | — | β: 0.059 | 2E-27 | PubMed |
| Type 2 diabetes | C | β: 0.045 | 4E-27 | PubMed |
| Type 2 diabetes | T | OR: 1.06 | 5E-23 | PubMed |
| Body mass index | C | β: 0.016 | 2E-22 | PubMed |
| Type 2 diabetes | T | β: 0.066 | 6E-21 | PubMed |
| Body mass index | T | β: 0.016 | 5E-17 | PubMed |
| Body mass index (MTAG) | T | β: 0.015 | 1E-16 | PubMed |
| Adult body size | T | β: 0.012 | 9E-15 | PubMed |
| Body mass index | C | β: 0.02 | 2E-14 | PubMed |
| Response to metformin in type 2 diabetes (HbA1c reduction) | C | OR: 0.17 | 7E-14 | PubMed |
| Body mass index | — | β: 0.017 | 2E-13 | PubMed |
| Hip circumference (UKB data field 49) | C | β: 0.014 | 8E-12 | PubMed |
| Glycated hemoglobin levels | T | β: 0.011 | 1E-11 | PubMed |
| Whole body fat mass (UKB data field 23100) | C | β: 0.018 | 1E-11 | PubMed |
| Type 2 diabetes and obsessive compulsive disorder | — | — | 3E-11 | PubMed |
| Fasting plasma glucose | C | β: 0.087 | 8E-11 | PubMed |
| Type 2 diabetes | T | β: 0.06 | 2E-9 | PubMed |
| Type 2 diabetes | T | OR: 1.05 | 1E-7 | PubMed |