Genetic variant
rs8068318
rs8068318 is a single-letter difference in human DNA, on chromosome 17. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs8068318 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Transferability and fine-mapping of genome-wide associated loci for adult height across human popula...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs8068318, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs8068318
- Position
- chr17:61406405
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| magnesium (Mg, mean, inv-norm transformed) | C | β 0.084 | 8E-72 | PubMed |
| magnesium (Mg, minimum, inv-norm transformed) | C | β 0.071 | 8E-53 | PubMed |
| magnesium (Mg, mean, inv-norm transformed) | C | β 0.061 | 2E-49 | PubMed |
| magnesium (Mg, minimum, inv-norm transformed) | C | β 0.053 | 1E-38 | PubMed |
| Diastolic blood pressure | T | OR 0.25 | 3E-18 | PubMed |
| Diastolic blood pressure | C | OR 0.26 | 3E-18 | PubMed |
| Systolic blood pressure | T | OR 0.41 | 2E-17 | PubMed |
| Systolic blood pressure | C | OR 0.42 | 4E-17 | PubMed |
| Estimated glomerular filtration rate | T | OR 0.52 | 2E-14 | PubMed |
| Hypertension | T | OR 6.96 | 3E-12 | PubMed |
| Creatinine levels | G | OR 0.8 | 3E-10 | PubMed |
| Mean arterial pressure | C | OR 0.28 | 2E-8 | PubMed |
| Pulse pressure | T | OR 0.17 | 3E-7 | PubMed |
| Mean arterial pressure | T | OR 0.26 | 3E-6 | PubMed |
| Diastolic blood pressure | T | OR 0.22 | 9E-6 | PubMed |
| Vaginal microbiome MetaCyc pathway (PWY-1622|formaldehyde assimilation I (serine pathway)) | T | OR 0.23 | 9E-6 | PubMed |
Sources
- dbSNP: rs8068318 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies