RS7903146 LOC110121472;TCF7L2
Upload your DNA to see your genotype for this variant.
What This Variant Does
"This SNP in TCF7L2 influences the risk of Type-2 diabetes (T2D). This SNP is also known as IVS3C>
Associated Conditions
Diabetes mellitus type 2
susceptibility to
Type 2 diabetes mellitus
Diabetes mellitus type 2
susceptibility to
Type 2 diabetes mellitus
Related Biomarkers
HbA1c (Glycated Hemoglobin)
risk if abnormal
strong
Glucose (Fasting)
risk if abnormal
strong
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Type 2 diabetes | T | — | 3E-1315 | PubMed |
| Type 2 diabetes | C | OR: 0.28 | 3E-695 | PubMed |
| Type 2 diabetes | C | OR: 0.4 | 6E-526 | PubMed |
| Type 2 diabetes | T | OR: 1.33 | 9E-471 | PubMed |
| Type 2 diabetes | T | OR: 1.37 | 6E-447 | PubMed |
| Type 2 diabetes | T | OR: 0.31 | 1E-347 | PubMed |
| Takes medication for Diabetes/sugar? | C | OR: 0.25 | 1E-302 | PubMed |
| Diabetic retinopathy (PheCode 250.7) | C | OR: 0.28 | 3E-271 | PubMed |
| Type 2 diabetes with ophthalmic manifestations (PheCode 250.23) | C | OR: 0.28 | 6E-259 | PubMed |
| Type 2 diabetes with neurological manifestations (PheCode 250.24) | C | OR: 0.2 | 8E-236 | PubMed |
| Glycated haemoglobin HbA1c levels (UKB data field 30750) | T | β: 0.065 | 8E-234 | PubMed |
| Type 2 diabetes | T | OR: 0.3 | 1E-219 | PubMed |
| Type 2 diabetes | — | — | 3E-203 | PubMed |
| Type 2 diabetes with neurological manifestations (PheCode 250.24) | C | OR: 0.2 | 7E-203 | PubMed |
| Medication use (drugs used in diabetes) | T | OR: 0.32 | 6E-175 | PubMed |
| Medication use (drugs used in diabetes) | T | OR: 0.33 | 4E-145 | PubMed |
| Type 2 diabetes (PheCode 250.2) | C | OR: 0.24 | 1E-140 | PubMed |
| Diabetes mellitus (PheCode 250) | C | OR: 0.24 | 1E-139 | PubMed |
| Type 2 diabetes | T | OR: 1.39 | 1E-139 | PubMed |
| Glucose (fasting status unknown, minimum, inv-norm transformed) | C | β: 0.062 | 3E-128 | PubMed |