rs7903146 a variant in the TCF7L2 gene

What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7903146 is the catalogue number of one of them, in the TCF7L2 gene. Which letters you carry there — one copy from each parent — is your genotype.

TCF7L2 (transcription factor 7 like 2): This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]

Gene description from NCBI Gene

This SNP in TCF7L2 influences the risk of Type-2 diabetes (T2D). This SNP is also known as IVS3C&gt

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Conditions it has been reported with

• Diabetes mellitus type 2, susceptibility to
• Type 2 diabetes mellitus

Listed in ClinVar submissions for this variant. Being listed is a report of an association, not a statement that the variant causes the condition in any given person.

Do I have this variant?

Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers related to TCF7L2

• HbA1c (Glycated Hemoglobin)
• Glucose (Fasting)

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

What should I do next?

1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.

This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID

rs7903146

Gene

TCF7L2

Position (GRCh38)

chr10:112998589

Variant type

snv

Consequence

intron variant

ClinVar classification

Likely risk allele

Genome-wide association studies (20)

ClinVar submissions (4)

How common the less frequent letter is

1kG AFR

74%

1kG ALL

77.2%

1kG AMR

76.5%

1kG EAS

2.3%

1kG EUR

31.7%

1kG SAS

29.9%

Sources

• dbSNP: rs7903146 — the reference record
• ClinVar — clinical interpretations submitted by laboratories
• SNPedia — community-written summaries
• NCBI Gene: TCF7L2
• Ensembl: TCF7L2
• GWAS Catalog — association studies

Related

Other variants in TCF7L2

• rs12255372
• rs11196205
• rs2137178800
• rs2136929776
• rs2137178349
• rs2544045443
• rs2137155220
• rs2136838531
• rs2137179429

• The TCF7L2 gene
• SNP explorer
• Gene directory
• Health conditions