Genetic variant
rs780093
rs780093 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs780093 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs780093, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs780093
- Position
- chr2:27519736
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglycerides | T | OR 0.14 | 3E-297 | PubMed |
| Estimated glomerular filtration rate | T | β 0.004 | 3E-62 | PubMed |
| Total cholesterol levels | T | β 0.069 | 1E-60 | PubMed |
| Triglyceride levels | — | β 0.068 | 3E-51 | PubMed |
| Total cholesterol levels | T | β 0.052 | 3E-47 | PubMed |
| Estimated glomerular filtration rate | C | OR 13.56 | 7E-42 | PubMed |
| Other chronic nonalcoholic liver disease (PheCode 571.5) | T | β 0.098 | 2E-38 | PubMed |
| Triglycerides to total lipids ratio in small HDL | T | β 0.051 | 3E-35 | PubMed |
| heart rate (HR, mean, inv-normal transformed) | T | β 0.033 | 4E-35 | PubMed |
| Triglycerides to total lipids ratio in medium HDL | T | β 0.048 | 4E-31 | PubMed |
| Weight (mean, inv-normal transformed) | T | β 0.033 | 9E-31 | PubMed |
| Total cholesterol levels | T | β 0.053 | 7E-30 | PubMed |
| AMBP/EFEMP1 protein level ratio | — | β 0.074 | 1E-27 | PubMed |
| Glucose (fasting status unknown, minimum, inv-norm transformed) | T | β 0.026 | 1E-26 | PubMed |
| Fasting plasma glucose | T | β 0.075 | 9E-24 | PubMed |
| Retinol (Vitamin A) levels | T | OR 0.1 | 1E-23 | PubMed |
| white blood cell count (WBC, mean, inv-norm transformed) | T | β 0.028 | 8E-23 | PubMed |
| Total cholesterol levels | — | OR 3.74 | 2E-22 | PubMed |
| CLSTN2/MATN2 protein level ratio | — | β 0.068 | 2E-22 | PubMed |
| Blood urea nitrogen (BUN, maximum, inv-norm transformed) | T | β 0.022 | 2E-22 | PubMed |
Sources
- dbSNP: rs780093 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies