Genetic variant
rs7775698
rs7775698 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7775698 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7775698, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7775698
- Position
- chr6:135097497
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean corpuscular volume | C | OR 0.73 | 3E-790 | PubMed |
| Red cell distribution width | C | — | 5E-429 | PubMed |
| Red cell distribution width | T | OR 0.12 | 1E-354 | PubMed |
| red cell diameter width (RDW, mean, inv-norm transformed) | C | OR 0.11 | 2E-299 | PubMed |
| mean corpuscular hemoglobin concentration (MCHC, minimum, inv-norm transformed) | C | OR 0.11 | 3E-285 | PubMed |
| Mean corpuscular hemoglobin | T | OR 0.22 | 1E-279 | PubMed |
| hematocrit (mean, inv-norm transformed) | C | OR 0.1 | 1E-267 | PubMed |
| Hematocrit | T | OR 0.1 | 9E-267 | PubMed |
| Mean corpuscular volume | T | OR 0.19 | 4E-225 | PubMed |
| EPO/TFRC protein level ratio | — | OR 0.24 | 6E-206 | PubMed |
| BCAM/EPO protein level ratio | — | OR 0.23 | 5E-195 | PubMed |
| Red blood cell count | T | OR 0.18 | 3E-178 | PubMed |
| red cell diameter width (RDW, maximum, inv-norm transformed) | C | β 0.083 | 3E-175 | PubMed |
| hematocrit (minimum, inv-norm transformed) | C | β 0.074 | 1E-150 | PubMed |
| Red cell distribution width | T | β 0.097 | 1E-108 | PubMed |
| Hemoglobin | T | β 0.068 | 2E-106 | PubMed |
| CA3/HMBS protein level ratio | — | OR 0.17 | 1E-104 | PubMed |
| hemoglobin (mean, inv-norm transformed) | C | β 0.06 | 4E-101 | PubMed |
| CA1/HMBS protein level ratio | — | OR 0.17 | 9E-100 | PubMed |
| Reticulocyte percentage (UKB data field 30240) | T | β 0.045 | 3E-93 | PubMed |
Sources
- dbSNP: rs7775698 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies