Genetic variant
rs77542162
rs77542162 is a single-letter difference in human DNA, on chromosome 17. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs77542162 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Rare and low-frequency coding variants alter human adult height.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs77542162, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs77542162
- Position
- chr17:69085137
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| DKKL1 protein levels | G | OR 0.2 | 4E-291 | PubMed |
| Low density lipoprotein cholesterol levels | — | — | 3E-275 | PubMed |
| ICAM5 protein levels | G | OR 0.4 | 4E-235 | PubMed |
| Low density lipoprotein cholesterol levels | G | OR 0.18 | 1E-212 | PubMed |
| Albumin levels | A | OR 0.24 | 2E-183 | PubMed |
| Total cholesterol levels | — | — | 1E-175 | PubMed |
| Low density lipoprotein cholesterol levels | A | OR 0.18 | 3E-169 | PubMed |
| DKK4 protein levels | G | OR 0.48 | 4E-162 | PubMed |
| Non-HDL cholesterol levels | — | — | 4E-146 | PubMed |
| CCL22 protein levels | G | OR 0.47 | 1E-134 | PubMed |
| Total cholesterol levels | G | OR 0.14 | 2E-130 | PubMed |
| Serum albumin levels | G | OR 0.19 | 1E-122 | PubMed |
| SMOC1 protein levels | G | OR 0.41 | 3E-121 | PubMed |
| Non-HDL cholesterol levels | G | OR 0.16 | 2E-111 | PubMed |
| Low density lipoprotein cholesterol levels | — | OR 0.18 | 2E-98 | PubMed |
| SRPX protein levels | G | OR 0.38 | 5E-87 | PubMed |
| Low-density lipoprotein levels | A | OR 0.15 | 2E-80 | PubMed |
| Corneal resistance factor | A | OR 0.47 | 2E-78 | PubMed |
| Corneal resistance factor (MTAG) | A | OR 0.25 | 3E-75 | PubMed |
| Direct low density lipoprotein levels (UKB data field 30780) | G | OR 0.13 | 7E-75 | PubMed |
Sources
- dbSNP: rs77542162 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies