Genetic variant
rs7744813
rs7744813 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7744813 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7744813, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7744813
- Position
- chr6:72933566
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Refractive error | — | — | 3E-205 | PubMed |
| Spherical equivalent | C | OR 0.2 | 3E-72 | PubMed |
| Refractive error (autorefraction measured) | A | OR 0.22 | 8E-64 | PubMed |
| Myopia | — | OR 1.13 | 2E-63 | PubMed |
| Myopia (PheCode 367.1) | C | β 0.09 | 2E-48 | PubMed |
| Spherical equivalent or myopia (age of diagnosis) | A | OR 14.56 | 5E-48 | PubMed |
| Myopia (age of diagnosis) | A | β 0.093 | 7E-38 | PubMed |
| Myopia (PheCode 367.1) | C | β 0.081 | 8E-37 | PubMed |
| Age-related eyesight deterioration (confirmatory factor analysis Factor 27) | — | — | 3E-36 | PubMed |
| Myopia | C | OR 0.15 | 2E-35 | PubMed |
| Hypermetropia (PheCode 367.8) | C | β 0.069 | 4E-31 | PubMed |
| Hypermetropia (PheCode 367.8) | C | β 0.064 | 2E-25 | PubMed |
| Ocular disease | — | — | 5E-23 | PubMed |
| Spherical equivalent (joint analysis main effects and education interaction) | A | — | 9E-16 | PubMed |
| Optic disc size | A | β 0.02 | 1E-15 | PubMed |
| Axial length | A | OR 0.1 | 9E-15 | PubMed |
| Primary angle-closure glaucoma (PheCode 365.2) | C | OR 0.13 | 7E-14 | PubMed |
| Primary angle-closure glaucoma (PheCode 365.2) | C | OR 0.11 | 2E-11 | PubMed |
| High myopia | — | OR 1.21 | 3E-11 | PubMed |
| Axial length | A | β 0.061 | 3E-10 | PubMed |
Sources
- dbSNP: rs7744813 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies