Genetic variant
rs769449
rs769449 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs769449 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs769449, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs769449
- Position
- chr19:44906745
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Apolipoprotein B levels | A | OR 0.31 | 3E-1621 | PubMed |
| C-reactive protein levels | A | OR 0.26 | 1E-1128 | PubMed |
| Low density lipoprotein cholesterol levels | A | OR 0.25 | 6E-1060 | PubMed |
| Total cholesterol levels | A | OR 0.22 | 6E-792 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | A | — | 1E-291 | PubMed |
| Apolipoprotein A1 levels | A | OR 0.11 | 4E-191 | PubMed |
| Low density lipoprotein cholesterol levels | G | OR 0.19 | 3E-157 | PubMed |
| Total cholesterol levels | G | OR 0.16 | 2E-114 | PubMed |
| High density lipoprotein cholesterol levels | A | β 0.086 | 4E-114 | PubMed |
| Amyloid beta 1-42 levels | A | OR 0.1 | 1E-107 | PubMed |
| Dementia with Lewy bodies | A | OR 2.32 | 3E-101 | PubMed |
| LDL cholesterol levels x short total sleep time interaction (2df test) | — | OR 7.5 | 1E-97 | PubMed |
| Cerebrospinal fluid AB1-42 levels | A | OR 0.1 | 5E-94 | PubMed |
| Dementia with Lewy bodies | A | OR 2.31 | 5E-94 | PubMed |
| Phospholipids in small HDL | A | β 0.09 | 1E-83 | PubMed |
| Longevity | A | β 0.058 | 6E-74 | PubMed |
| Aspartate aminotransferase to alanine aminotransferase ratio | A | β 0.066 | 9E-73 | PubMed |
| Triglyceride levels | A | β 0.06 | 1E-60 | PubMed |
| C-reactive protein levels | — | OR 0.25 | 3E-52 | PubMed |
| High density lipoprotein cholesterol levels | G | β 0.089 | 4E-52 | PubMed |
Sources
- dbSNP: rs769449 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies