RS769446 Unknown gene
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What This Variant Does
"An APOE Haplotype Associated with Decreased ?4 Expression Increases the Risk of Late Onset Alzheimer's Disease"
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Low density lipoprotein cholesterol levels | — | OR: 0.51 | 3E-322 | PubMed |
| Total cholesterol levels | — | OR: 0.28 | 6E-187 | PubMed |
| CEACAM16 protein levels | C | β: 0.096 | 2E-25 | PubMed |
| APOE protein levels | — | OR: 0.54 | 8E-24 | PubMed |
| Omega-6 fatty acids to total fatty acids percentage | — | — | 6E-20 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | — | — | 9E-20 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | — | — | 5E-18 | PubMed |
| Linoleic acid to total fatty acids percentage | — | — | 1E-17 | PubMed |
| Linoleic acid to total fatty acids percentage | — | — | 4E-15 | PubMed |
| Omega-6 fatty acids to total fatty acids percentage | — | — | 5E-15 | PubMed |
| Polyunsaturated fatty acids to total fatty acids percentage | — | — | 2E-14 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | — | — | 5E-14 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | — | — | 6E-13 | PubMed |
| SPTBN4 protein levels | — | OR: 0.35 | 2E-10 | PubMed |
| Polyunsaturated fatty acids to total fatty acids percentage | — | — | 4E-10 | PubMed |
| Coronary artery disease | T | OR: 1.34 | 2E-9 | PubMed |
| Polyunsaturated fatty acids to saturated fatty acids ratio | — | — | 2E-8 | PubMed |
| Omega-6 fatty acid levels | — | — | 3E-8 | PubMed |
| Omega-6 fatty acid levels | — | — | 4E-8 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | — | — | 5E-8 | PubMed |