Genetic variant
rs7568458
rs7568458 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7568458 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7568458, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7568458
- Position
- chr2:85561052
Genome-wide association studies (14)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Coronary atherosclerosis (PheCode 411.4) | T | β 0.051 | 6E-21 | PubMed |
| Ischemic heart disease (PheCode 411) | T | β 0.046 | 7E-19 | PubMed |
| red cell diameter width (RDW, minimum, inv-norm transformed) | T | β 0.023 | 1E-18 | PubMed |
| red cell diameter width (RDW, mean, inv-norm transformed) | T | β 0.021 | 2E-15 | PubMed |
| Myocardial infarction (PheCode 411.2) | T | β 0.052 | 1E-13 | PubMed |
| Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) | A | OR 1.06 | 2E-13 | PubMed |
| Prostate cancer | T | OR 1.11 | 1E-12 | PubMed |
| Prostate cancer | — | β 0.1 | 4E-12 | PubMed |
| Weight | A | β 0.008 | 1E-11 | PubMed |
| Coronary artery disease | A | OR 1.06 | 4E-10 | PubMed |
| Prostate cancer | A | OR 0.1 | 1E-9 | PubMed |
| Cancer (pleiotropy) | T | OR 1.1 | 6E-9 | PubMed |
| Prostate cancer | — | OR 0.9 | 4E-7 | PubMed |
| Prostate cancer (late onset) | — | OR 0.9 | 2E-6 | PubMed |
Sources
- dbSNP: rs7568458 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies