Genetic variant
rs755109
rs755109 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs755109 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
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From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs755109, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs755109
- Position
- chr9:97933921
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| DOK2/GRAP2 protein level ratio | — | OR 0.13 | 7E-80 | PubMed |
| DAB2/GRAP2 protein level ratio | — | OR 0.11 | 7E-54 | PubMed |
| IPCEF1/TBCC protein level ratio | — | OR 0.11 | 3E-53 | PubMed |
| IPCEF1/TBCB protein level ratio | — | OR 0.1 | 2E-48 | PubMed |
| GRAP2/NCK2 protein level ratio | — | OR 0.11 | 2E-48 | PubMed |
| DAG1/SCARF1 protein level ratio | — | OR 0.1 | 3E-46 | PubMed |
| GRAP2/IRAK4 protein level ratio | — | OR 0.1 | 1E-45 | PubMed |
| DOK2/PDLIM7 protein level ratio | — | β 0.096 | 2E-41 | PubMed |
| GRAP2/MAP4K5 protein level ratio | — | β 0.09 | 8E-36 | PubMed |
| ERBIN/LAT2 protein level ratio | — | β 0.085 | 6E-33 | PubMed |
| CDKN2D/TBL1X protein level ratio | — | β 0.086 | 1E-32 | PubMed |
| LYN/SIRT2 protein level ratio | — | β 0.085 | 1E-32 | PubMed |
| MPHOSPH8/VASH1 protein level ratio | — | β 0.083 | 3E-30 | PubMed |
| LAT2/YES1 protein level ratio | — | β 0.081 | 9E-30 | PubMed |
| CD40/VSIR protein level ratio | — | β 0.079 | 6E-28 | PubMed |
| METAP1D/VASH1 protein level ratio | — | β 0.074 | 4E-25 | PubMed |
| IKBKG/TRIM5 protein level ratio | — | β 0.072 | 3E-24 | PubMed |
| SRPK2/VASH1 protein level ratio | — | β 0.071 | 8E-24 | PubMed |
| MGLL/PLA2G4A protein level ratio | — | β 0.072 | 8E-24 | PubMed |
| GP6/TMSB10 protein level ratio | — | β 0.07 | 2E-23 | PubMed |
Sources
- dbSNP: rs755109 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies