Genetic variant
rs737337
rs737337 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs737337 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs737337, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs737337
- Position
- chr19:11236817
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| High density lipoprotein cholesterol levels | T | β 0.054 | 7E-22 | PubMed |
| HDL cholesterol levels | T | β 0.057 | 1E-21 | PubMed |
| HDL cholesterol levels | T | β 0.015 | 2E-21 | PubMed |
| High density lipoprotein cholesterol levels | — | OR 1.18 | 1E-20 | PubMed |
| Phospholipids in HDL (UKB data field 23414) | C | β 0.073 | 1E-19 | PubMed |
| Concentration of medium HDL particles (UKB data field 23565) | C | β 0.074 | 1E-19 | PubMed |
| Apolipoprotein A1 levels (UKB data field 23440) | C | β 0.071 | 3E-18 | PubMed |
| Free cholesterol in medium HDL (UKB data field 23570) | C | β 0.07 | 4E-18 | PubMed |
| Total lipids in HDL (UKB data field 23426) | C | β 0.07 | 6E-18 | PubMed |
| Cholesterol in medium HDL (UKB data field 23568) | C | β 0.07 | 1E-17 | PubMed |
| Cholesteryl esters in medium HDL (UKB data field 23569) | C | β 0.07 | 3E-17 | PubMed |
| HDL cholesterol | C | β 0.056 | 5E-17 | PubMed |
| Concentration of HDL particles (UKB data field 23430) | C | β 0.067 | 8E-16 | PubMed |
| Total cholesterol levels | — | OR 3.14 | 1E-15 | PubMed |
| HDL cholesterol levels | C | OR 0.11 | 2E-15 | PubMed |
| Total concentration of lipoprotein particles (UKB data field 23427) | C | β 0.064 | 2E-14 | PubMed |
| HDL cholesterol levels (UKB data field 23406) | C | β 0.061 | 2E-14 | PubMed |
| Free cholesterol in HDL (UKB data field 23422) | C | β 0.06 | 3E-14 | PubMed |
| Cholesteryl esters in HDL (UKB data field 23418) | C | β 0.061 | 4E-14 | PubMed |
| Phospholipids in large HDL (UKB data field 23560) | C | β 0.058 | 3E-13 | PubMed |
Sources
- dbSNP: rs737337 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies