Genetic variant

rs73015965 a variant in the PLG gene

rs73015965 is a single-letter difference in the PLG gene, on chromosome 6. ClinVar, the public archive of variant interpretations, lists it as likely pathogenic: probably able to cause or contribute to disease. It has been reported in connection with Plasminogen deficiency, type I and Otitis media, susceptibility to, among others. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs73015965 is the catalogue number of one of them, in the PLG gene. Which letters you carry there — one copy from each parent — is your genotype.

PLG (plasminogen): The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor).

Gene description from NCBI Gene

Why might it matter?

ClinVar records this variant as likely pathogenic, meaning probably able to cause or contribute to disease. A classification describes the variant, not you: what it means for one person depends on their genotype, their family history and often on other genes and circumstances.

Conditions it has been reported with

Listed in ClinVar submissions for this variant. Being listed is a report of an association, not a statement that the variant causes the condition in any given person.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs73015965, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs73015965
Gene
PLG
Position
chr6:160706469
ClinVar classification
Pathogenic/Likely pathogenic

Genome-wide association studies (12)

TraitRisk alleleOR / betaP-valueStudy
Lipoprotein A levels (UKB data field 30790) G OR 0.31 9E-101 PubMed
KRT5 protein levels G OR 0.63 2E-64 PubMed
CES3 protein levels G OR 0.54 1E-46 PubMed
LPA protein levels G OR 0.42 3E-28 PubMed
TXNDC15 protein levels G OR 0.27 7E-26 PubMed
MYL3 protein levels G OR 0.31 2E-17 PubMed
BTD protein levels G OR 0.27 2E-15 PubMed
C4BPB protein levels G OR 0.27 4E-14 PubMed
CD99L2 protein levels G OR 0.29 1E-13 PubMed
ASGR2 protein levels G OR 0.26 2E-13 PubMed
Childhood ear infection — OR 1.43 4E-8 PubMed
Childhood ear infection G OR 1.43 4E-8 PubMed

Sources