Genetic variant
rs727428
rs727428 is a single-letter difference in human DNA, on chromosome 17. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs727428 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs727428 is a SNP in the sex-hormone binding globulin SHBG gene. SHBG binds steroid hormones, mostly...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs727428, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs727428
- Position
- chr17:7634474
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Bioavailable testosterone levels | T | β 0.095 | 8E-309 | PubMed |
| Free testosterone levels | — | OR 0.11 | 1E-233 | PubMed |
| Sex hormone-binding globulin levels | C | OR 7.25 | 5E-109 | PubMed |
| Bioavailable testosterone levels | C | β 0.02 | 1E-48 | PubMed |
| Free testosterone levels | C | β 0 | 2E-46 | PubMed |
| Total testosterone levels | C | OR 0.11 | 2E-34 | PubMed |
| Hemoglobin A1c levels | C | β 0.024 | 2E-32 | PubMed |
| Bioavailable testosterone levels | C | β 0.02 | 3E-25 | PubMed |
| Bioavailable testosterone levels | C | β 0.03 | 7E-23 | PubMed |
| Hypogonadism | C | OR 0.18 | 9E-23 | PubMed |
| Free testosterone levels | C | β 0 | 5E-21 | PubMed |
| Sex hormone-binding globulin (analyte X4929.55) levels | T | OR 0.21 | 8E-20 | PubMed |
| Waist-to-hip ratio adjusted for BMI | T | β 0.016 | 2E-18 | PubMed |
| Cholesterol to Total Lipids in Large HDL percentage | C | β 0.02 | 4E-18 | PubMed |
| Waist-to-hip ratio adjusted for BMI | T | β 0.016 | 4E-18 | PubMed |
| Waist-to-hip ratio adjusted for BMI | — | — | 2E-17 | PubMed |
| Cholesteryl Esters to Total Lipids in Large HDL percentage | C | β 0.02 | 2E-17 | PubMed |
| Sex hormone-binding globulin levels | T | OR 0.13 | 2E-16 | PubMed |
| Sex hormone-binding globulin levels | T | OR 0.22 | 2E-16 | PubMed |
| Waist-hip index | T | β 0.023 | 4E-16 | PubMed |
Sources
- dbSNP: rs727428 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies