RS727428 Unknown gene
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What This Variant Does
"rs727428 is a SNP in the sex-hormone binding globulin SHBG gene. SHBG binds steroid hormones, mostly..."
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Bioavailable testosterone levels | T | β: 0.095 | 8E-309 | PubMed |
| Free testosterone levels | — | OR: 0.11 | 1E-233 | PubMed |
| Sex hormone-binding globulin levels | C | OR: 7.25 | 5E-109 | PubMed |
| Bioavailable testosterone levels | C | β: 0.02 | 1E-48 | PubMed |
| Free testosterone levels | C | β: 0 | 2E-46 | PubMed |
| Total testosterone levels | C | OR: 0.11 | 2E-34 | PubMed |
| Hemoglobin A1c levels | C | β: 0.024 | 2E-32 | PubMed |
| Bioavailable testosterone levels | C | β: 0.02 | 3E-25 | PubMed |
| Bioavailable testosterone levels | C | β: 0.03 | 7E-23 | PubMed |
| Hypogonadism | C | OR: 0.18 | 9E-23 | PubMed |
| Free testosterone levels | C | β: 0 | 5E-21 | PubMed |
| Sex hormone-binding globulin (analyte X4929.55) levels | T | OR: 0.21 | 8E-20 | PubMed |
| Waist-to-hip ratio adjusted for BMI | T | β: 0.016 | 2E-18 | PubMed |
| Cholesterol to Total Lipids in Large HDL percentage | C | β: 0.02 | 4E-18 | PubMed |
| Waist-to-hip ratio adjusted for BMI | T | β: 0.016 | 4E-18 | PubMed |
| Waist-to-hip ratio adjusted for BMI | — | — | 2E-17 | PubMed |
| Cholesteryl Esters to Total Lipids in Large HDL percentage | C | β: 0.02 | 2E-17 | PubMed |
| Sex hormone-binding globulin levels | T | OR: 0.13 | 2E-16 | PubMed |
| Sex hormone-binding globulin levels | T | OR: 0.22 | 2E-16 | PubMed |
| Waist-hip index | T | β: 0.023 | 4E-16 | PubMed |