Genetic variant

rs72660908

rs72660908 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs72660908 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

The top SNP rs72660908 perfectly tags the RHD gene deletion as detected by copy number variation an...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs72660908, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs72660908
Position
chr1:25257119

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Intercellular adhesion molecule 4 levels C OR 0.62 4E-539 PubMed
Intercellular adhesion molecule 4 levels (ICAM4.6550.4.3) G OR 0.62 5E-159 PubMed
Serum levels of protein ICAM4 G OR 0.48 8E-148 PubMed
Serum levels of protein ICAM4 G OR 0.46 8E-134 PubMed
platelet count (maximum, inv-norm transformed) C β 0.047 1E-60 PubMed
erythrocyte sedimentation rate (ESR, minimum, inv-norm transformed) C β 0.077 3E-33 PubMed
erythrocyte sedimentation rate (ESR, mean, inv-norm transformed) C β 0.076 5E-33 PubMed
platelet count (mean, inv-norm transformed) C β 0.042 1E-30 PubMed
Mean corpuscular hemoglobin — — 6E-30 PubMed
erythrocyte sedimentation rate (ESR, maximum, inv-norm transformed) C β 0.072 2E-29 PubMed
platelet count (maximum, inv-norm transformed) C β 0.038 7E-27 PubMed
Mean corpuscular haemoglobin (UKB data field 30050) G β 0.018 6E-24 PubMed
mean corpuscular volume (MCV, mean, inv-norm transformed) C β 0.032 3E-19 PubMed
mean corpuscular volume (MCV, minimum, inv-norm transformed) C β 0.031 6E-19 PubMed
mean corpuscular volume (MCV, maximum, inv-norm transformed) C β 0.03 4E-17 PubMed
Total lipids in very large HDL G β 0.01 7E-16 PubMed
Red cell distribution width G β 0.025 4E-15 PubMed
Phospholipids in very large HDL G β 0.01 3E-14 PubMed
Concentration of large HDL particles G β 0.01 2E-13 PubMed
Free cholesterol in large HDL G β 0.01 4E-13 PubMed

Sources