Genetic variant
rs7259004
rs7259004 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7259004 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7259004, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7259004
- Position
- chr19:44929300
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Apolipoprotein B levels | C | OR 0.21 | 1E-621 | PubMed |
| Low density lipoprotein cholesterol levels | C | OR 0.16 | 1E-357 | PubMed |
| Total cholesterol levels | C | OR 0.11 | 4E-173 | PubMed |
| Triglyceride levels | C | β 0.089 | 2E-117 | PubMed |
| APOE protein levels | — | OR 0.52 | 3E-23 | PubMed |
| Lipoprotein (a) levels | C | β 0.039 | 3E-19 | PubMed |
| Metabolic syndrome | — | β 0.022 | 6E-17 | PubMed |
| Omega-3 fatty acid levels | C | — | 1E-16 | PubMed |
| Monounsaturated fatty acid levels | C | — | 5E-16 | PubMed |
| Omega-3 fatty acid levels | C | — | 2E-13 | PubMed |
| 1-oleoylglycerol (18:1) levels | C | OR 0.12 | 2E-13 | PubMed |
| Sphingomyelin_38:1_[M+H]1+ levels | C | OR 0.14 | 6E-13 | PubMed |
| 1-stearoyl-2-linoleoyl-GPE (18:0/18:2) levels | C | OR 0.11 | 2E-12 | PubMed |
| 1-stearoyl-2-oleoyl-GPE (18:0/18:1) levels | C | OR 0.11 | 1E-11 | PubMed |
| Sphingomyelin_40:1_[M+H]1+ levels | C | OR 0.16 | 6E-11 | PubMed |
| Triacylglycerol_46:4_[M+NH4]1+ levels | C | OR 0.15 | 7E-11 | PubMed |
| Phosphatidylglycerol-O_42:0_[M-H]1- levels | C | β 0.094 | 1E-10 | PubMed |
| Sphingomyeline C24:0 levels | C | β 0.091 | 2E-10 | PubMed |
| Sphingolipid levels | — | β 0 | 5E-10 | PubMed |
| Saturated fatty acids to total fatty acids percentage | C | — | 2E-9 | PubMed |
Sources
- dbSNP: rs7259004 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies