Genetic variant

rs7241918

rs7241918 is a single-letter difference in human DNA, on chromosome 18. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7241918 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7241918, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs7241918
Position
chr18:49634583

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Phospholipid levels in medium HDL G OR 0.1 5E-87 PubMed
Total lipid levels in medium HDL G β 0.097 8E-84 PubMed
Phospholipid levels in HDL G β 0.095 2E-83 PubMed
Concentration of medium HDL particles G β 0.096 4E-83 PubMed
Apolipoprotein A1 levels G β 0.095 3E-81 PubMed
Total lipid levels in HDL G β 0.09 2E-76 PubMed
Free cholesterol levels in medium HDL G β 0.091 2E-75 PubMed
Cholesterol levels in medium HDL G β 0.087 3E-68 PubMed
Phospholipids in HDL (UKB data field 23414) G β 0.097 1E-66 PubMed
Cholesteryl ester levels in medium HDL G β 0.086 1E-65 PubMed
Total lipids in HDL (UKB data field 23426) G β 0.092 8E-61 PubMed
Free cholesterol levels in HDL G β 0.077 2E-58 PubMed
HDL cholesterol levels G β 0.076 4E-55 PubMed
Cholesteryl ester levels in HDL G β 0.075 8E-53 PubMed
HDL cholesterol G OR 1.31 3E-49 PubMed
Free cholesterol in HDL (UKB data field 23422) G β 0.08 1E-46 PubMed
HDL cholesterol G β 0.09 1E-44 PubMed
Phospholipid levels in large HDL G β 0.066 7E-44 PubMed
High density lipoprotein cholesterol levels G β 0.064 1E-40 PubMed
Total lipid levels in large HDL G β 0.062 1E-38 PubMed

Sources