Genetic variant
rs7232
rs7232 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7232 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7232, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7232
- Position
- chr11:60173126
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| MFGE8 protein levels | A | OR 0.16 | 3E-210 | PubMed |
| Triggering receptor expressed on myeloid cells 2 levels | A | OR 0.37 | 3E-190 | PubMed |
| Lactosylceramide 4-alpha-galactosyltransferase levels | A | OR 0.29 | 1E-101 | PubMed |
| DKK4 protein levels | A | β 0.061 | 7E-31 | PubMed |
| Glycolipid transfer protein domain-containing protein 2 levels | A | OR 0.15 | 1E-27 | PubMed |
| Alzheimer's disease | A | — | 2E-26 | PubMed |
| PLA2G10 protein levels | A | β 0.056 | 1E-25 | PubMed |
| Serum levels of protein GLTPD2 | A | OR 0.19 | 2E-25 | PubMed |
| F7 protein levels | A | β 0.048 | 1E-22 | PubMed |
| LGALS3BP protein levels | A | β 0.052 | 4E-21 | PubMed |
| PT international normalized ratio (INR, minimum, inv-norm transformed) | T | β 0.033 | 1E-17 | PubMed |
| Lymphocyte percentage of white cells | A | β 0.02 | 2E-17 | PubMed |
| C1QTNF5 protein levels | A | β 0.048 | 4E-17 | PubMed |
| MEGF10 protein levels | A | β 0.041 | 1E-16 | PubMed |
| FOLR2 protein levels | A | β 0.044 | 1E-16 | PubMed |
| FCRLB protein levels | A | β 0.038 | 2E-16 | PubMed |
| LILRB2 protein levels | A | β 0.033 | 4E-16 | PubMed |
| Cerebrospinal fluid sTREM-2 levels | — | β 1076.507 | 1E-14 | PubMed |
| APOD protein levels | A | β 0.041 | 8E-14 | PubMed |
| Cerebrospinal fluid sTREM-2 levels | A | OR 0.49 | 2E-11 | PubMed |
Sources
- dbSNP: rs7232 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies