Genetic variant

rs7200543

rs7200543 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7200543 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7200543, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs7200543
Position
chr16:15036113

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Docosahexaenoic acid levels G — 2E-140 PubMed
Cholesteryl ester_20:3_[M+NH4]1+ levels G OR 0.17 3E-54 PubMed
1-stearoyl-2-dihomo-linolenoyl-GPC (18:0/20:3n3 or 6) levels A OR 0.17 8E-54 PubMed
Phosphatidylcholine_38:2_[M+H]1+/Phosphatidylethanolamine_41:2_[M+H]1+ levels G OR 0.24 1E-49 PubMed
Phosphatidylcholine_38:3_[M+H]1+/Phosphatidylethanolamine_41:3_[M+H]1+/Phosphatidate_43:4_[M+NH4]1+ levels G OR 0.22 3E-40 PubMed
Phosphatidylcholine diacyl C38:3 levels A OR 13.12 3E-39 PubMed
Height G β 0.022 4E-21 PubMed
Phosphatidylcholine_37:3_[M+OAc]1-/Phosphatidylserine_41:2_[M-H]1- levels G β 0.081 1E-17 PubMed
Phosphatidylcholine diacyl C38:3 levels A β 0.041 3E-17 PubMed
Body mass index G β 0.012 8E-17 PubMed
Metabolic traits G β 0.073 5E-16 PubMed
Fatty acid(20:3)_[M-H]1- levels G β 0.065 3E-15 PubMed
Phosphatidylcholine_34:2_[M+H]1+/Phosphatidylethanolamine_37:2_[M+H]1+/Phosphatidate_39:3_[M+NH4]1+ levels G β 0.096 5E-15 PubMed
Phosphatidylcholine diacyl C36:3 levels A OR 7.3 3E-13 PubMed
Phosphatidylcholine diacyl C36:4 levels A OR 7.26 4E-13 PubMed
Phosphatidylcholine_35:2_[M+H]1+/Phosphatidylethanolamine_38:2_[M+H]1+/Phosphatidate_40:3_[M+NH4]1+ levels G β 0.091 2E-12 PubMed
Serum albumin levels G β 0.015 2E-11 PubMed
Phosphatidylcholine(36:3)_[M+H]1+/Phosphatidylethanolamine(39:3)_[M+H]1+/Phosphatidate(41:4)_[M+NH4]1+ levels A β 0.063 2E-10 PubMed
Phosphatidylethanolamine(40:2)_[M-H]1- levels C β 0.057 2E-10 PubMed
Phosphatidylcholine(38:3)_[M+H]1+/Phosphatidylethanolamine(41:3)_[M+H]1+/Phosphatidate(43:4)_[M+NH4]1+ levels C β 0.059 2E-10 PubMed

Sources