Genetic variant
rs715
rs715 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs715 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs715, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs715
- Position
- chr2:210678331
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Glycine levels | C | OR 0.44 | 3E-1632 | PubMed |
| Glycine levels | C | OR 86.63 | 3E-1632 | PubMed |
| Glycine levels | T | β 0.076 | 2E-147 | PubMed |
| Citrate levels | C | β 0.059 | 9E-86 | PubMed |
| Serine levels | C | OR 19.41 | 6E-84 | PubMed |
| Plasma free amino acid levels (adjusted for twenty other PFAAs) | T | OR 0.72 | 2E-75 | PubMed |
| Urine 3-methylglutarate/2-methylglutarate levels in chronic kidney disease | C | OR 0.33 | 1E-74 | PubMed |
| N-acetylglycine levels | T | β 0.091 | 7E-58 | PubMed |
| Metabolite levels | T | OR 0.61 | 3E-50 | PubMed |
| Metabolite levels (hexanoylglycine) | C | OR 0.36 | 7E-44 | PubMed |
| Tyrosine levels | C | β 0.03 | 5E-35 | PubMed |
| X-08988 levels | T | β 0.033 | 7E-35 | PubMed |
| Urate levels | T | β 0.024 | 1E-32 | PubMed |
| Creatine levels | C | OR 0.18 | 2E-30 | PubMed |
| Eosinophill percentage (UKB data field 30210) | C | β 0.024 | 7E-30 | PubMed |
| Urine X-24406 levels in chronic kidney disease | C | OR 0.25 | 7E-28 | PubMed |
| Eosinophil percentage of white cells | C | β 0.026 | 4E-27 | PubMed |
| Glutamine degradant levels | C | OR 0.15 | 4E-27 | PubMed |
| Histidine levels | T | OR 10.76 | 6E-27 | PubMed |
| Urine cis-3,4-methyleneheptanoylglycine levels in chronic kidney disease | C | OR 0.24 | 1E-26 | PubMed |
Sources
- dbSNP: rs715 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies