Genetic variant
rs71390846
rs71390846 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs71390846 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs71390846, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs71390846
- Position
- chr16:86681109
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Heel bone mineral density | — | β 0.045 | 2E-71 | PubMed |
| Heel bone mineral density | — | — | 2E-70 | PubMed |
| Heel bone mineral density | G | β 0.039 | 6E-59 | PubMed |
| Bone density (confirmatory factor analysis Factor 19) | — | — | 4E-15 | PubMed |
| Height | C | β 0.012 | 5E-15 | PubMed |
| DXA-Bone mineral density (femur neck) (UKB data field 23299) | C | β 0.072 | 1E-11 | PubMed |
| Femoral neck bone mineral density | C | β 0.06 | 2E-11 | PubMed |
| Brain shape (segment 5) | — | — | 2E-11 | PubMed |
| DXA-Bone mineral density (total body) (UKB data field 23236) | C | β 0.071 | 3E-11 | PubMed |
| Epiretinal membrane | — | β 0.069 | 4E-11 | PubMed |
| Bone mineral density (spine) | — | — | 2E-10 | PubMed |
| DXA-Bone mineral density (pelvis) (UKB data field 23232) | C | β 0.067 | 3E-10 | PubMed |
| DXA-Bone mineral density (femur total) (UKB data field 23291) | C | β 0.066 | 5E-10 | PubMed |
| DXA-Bone mineral density (lumbar spine) | C | β 0.068 | 6E-10 | PubMed |
| Total body bone mineral density | C | β 0.05 | 7E-10 | PubMed |
| DXA-Bone mineral density (legs) (UKB data field 23231) | C | β 0.065 | 1E-9 | PubMed |
| Lumbar spine bone mineral density | C | β 0.061 | 1E-9 | PubMed |
| Heel bone mineral density | G | β 0.037 | 1E-8 | PubMed |
| Bone mineral density (hip) | — | β 0.09 | 3E-8 | PubMed |
| DXA-Bone mineral density (trunk) (UKB data field 23241) | C | β 0.058 | 4E-8 | PubMed |
Sources
- dbSNP: rs71390846 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies