Genetic variant
rs710446
rs710446 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs710446 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs710446, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs710446
- Position
- chr3:186742138
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Coagulation Factor XI levels | T | OR 0.52 | 2E-352 | PubMed |
| Plasma kallikrein levels | T | OR 0.51 | 7E-345 | PubMed |
| Fibrinogen levels or factor VII levels or factor XI levels or tissue plasminogen activator levels (pleiotropy) | — | — | 5E-324 | PubMed |
| Ischemic stroke or factor XI levels (pleiotropy) | — | — | 5E-307 | PubMed |
| Venous thromboembolism or factor XI levels (pleiotropy) | — | — | 6E-304 | PubMed |
| Factor XI | — | β 0.089 | 2E-302 | PubMed |
| Coronary artery disease or factor XI levels (pleiotropy) | — | — | 6E-294 | PubMed |
| Activated partial thromboplastin time | C | OR 1.18 | 2E-203 | PubMed |
| Serum levels of protein F11 | C | OR 0.42 | 5E-171 | PubMed |
| Serum levels of protein KLKB1 | C | OR 0.47 | 4E-157 | PubMed |
| Coagulation Factor XI levels | C | OR 0.53 | 2E-83 | PubMed |
| Kininostatin levels | T | OR 0.25 | 4E-80 | PubMed |
| Plasma kallikrein levels | C | OR 0.5 | 3E-73 | PubMed |
| AGRP/NPY protein level ratio | — | OR 0.1 | 6E-52 | PubMed |
| ITGA6/STX8 protein level ratio | — | β 0.093 | 1E-40 | PubMed |
| ESAM/SPINT2 protein level ratio | — | β 0.089 | 5E-37 | PubMed |
| SPINT2 protein levels | C | β 0.063 | 2E-31 | PubMed |
| MOES protein level (protein group normalized intensity) | C | OR 0.36 | 2E-27 | PubMed |
| WAS protein levels | C | β 0.063 | 4E-24 | PubMed |
| CAPN3 protein levels | C | β 0.064 | 1E-23 | PubMed |
Sources
- dbSNP: rs710446 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies