Genetic variant
rs706778
rs706778 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs706778 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs706778 is mentioned as being strongly associated with type-1 diabetes in [GWAS:Rheumatoid arthrit...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs706778, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs706778
- Position
- chr10:6056986
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Hypothyroidism (PheCode 244) | C | β 0.054 | 1E-21 | PubMed |
| Hypothyroidism NOS (PheCode 244.4) | C | β 0.054 | 3E-21 | PubMed |
| Rheumatoid arthritis or type 1 diabetes | — | — | 6E-20 | PubMed |
| Autoimmune traits | — | — | 4E-18 | PubMed |
| Thyroid problems | C | β 0.066 | 2E-16 | PubMed |
| Takes medication for Thyroid problems? | C | β 0.071 | 3E-15 | PubMed |
| Lymphocytic thyroiditis | T | OR 0.11 | 1E-14 | PubMed |
| Rheumatoid arthritis | T | OR 1.1 | 5E-14 | PubMed |
| Rheumatoid arthritis (MTAG) | C | β 0.036 | 6E-14 | PubMed |
| Other non-epithelial cancer of skin (PheCode 172.2) | C | β 0.04 | 9E-13 | PubMed |
| Arthritis (juvenile idiopathic) | T | OR 1.17 | 1E-12 | PubMed |
| Thyroid problems | C | β 0.056 | 5E-12 | PubMed |
| Rheumatoid arthritis | T | OR 0.11 | 7E-12 | PubMed |
| Rheumatoid arthritis | T | OR 1.12 | 1E-11 | PubMed |
| Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) | T | OR 1.09 | 1E-11 | PubMed |
| Pediatric autoimmune diseases | T | — | 6E-9 | PubMed |
Sources
- dbSNP: rs706778 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies