Genetic variant
rs7041
rs7041 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7041 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A study of 414 (ex)-smokers older than 50 years concluded that vitamin D levels were reduced by 25%
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Supplements
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7041, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers related to
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7041
- Position
- chr4:71752617
Genome-wide association studies (9)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Vitamin D-binding protein levels | — | OR 1.02 | 1E-7245 | PubMed |
| Serum vitamin D-binding protein levels | T | β 2109.34 | 1E-246 | PubMed |
| Serum vitamin D-binding protein levels in type 2 diabetes | — | OR 0.44 | 9E-86 | PubMed |
| VDBP plasma levels | C | OR 0.57 | 6E-57 | PubMed |
| Vitamin D-binding protein levels | C | OR 0.61 | 1E-48 | PubMed |
| Bioavailable vitamin D levels in type 2 diabetes | — | OR 0.16 | 3E-19 | PubMed |
| Protein jagged-1 levels (JAG1.5092.51.3) | C | OR 0.22 | 4E-19 | PubMed |
| Vitamin D insufficiency | — | OR 0.79 | 2E-9 | PubMed |
| Serum 25-Hydroxyvitamin D levels | C | OR 5.3 | 1E-7 | PubMed |
Sources
- dbSNP: rs7041 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies