Genetic variant
rs6968865
rs6968865 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6968865 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs6968865 is a SNP located near the aryl hydrocarbon receptor AHR gene on ch 7p21. A meta-analysis o...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6968865, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6968865
- Position
- chr7:17247645
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| F-chocolate/coffee liking (derived food-liking factor) | T | OR 0.16 | 2E-25 | PubMed |
| 1-methylurate levels | A | OR 0.11 | 1E-23 | PubMed |
| Estimated glomerular filtration rate (creatinine) | T | OR 9.86 | 6E-23 | PubMed |
| Coffee max liking | T | β 0.035 | 7E-22 | PubMed |
| Estimated glomerular filtration rate (creatinine) | T | β 0.021 | 7E-22 | PubMed |
| Creatinine levels (UKB data field 30700) | T | β 0.015 | 2E-21 | PubMed |
| Triglyceride levels in non-type 2 diabetes | — | — | 3E-18 | PubMed |
| Estimated glomerular filtration rate (creatinine) | A | β 0.002 | 9E-17 | PubMed |
| Triglyceride levels (UKB data field 30870) | T | β 0.016 | 1E-16 | PubMed |
| Coffee consumption (cups per day) | — | β 0.03 | 4E-15 | PubMed |
| Urea levels (UKB data field 30670) | T | β 0.015 | 1E-14 | PubMed |
| Triglyceride levels | A | β 0.015 | 8E-14 | PubMed |
| Estimated glomerular filtration rate (creatinine, cystatin c) | T | β 0.015 | 2E-13 | PubMed |
| Glycated haemoglobin HbA1c levels (UKB data field 30750) | T | β 0.013 | 9E-13 | PubMed |
| Coffee consumption | T | OR 0.26 | 2E-11 | PubMed |
| Ratio of apolipoprotein B to apolipoprotein A1 levels | A | β 0.028 | 3E-11 | PubMed |
| Concentration of small VLDL particles | A | β 0.028 | 3E-11 | PubMed |
| Free cholesterol in small VLDL | A | β 0.028 | 5E-11 | PubMed |
| Total lipids in small VLDL | A | β 0.028 | 5E-11 | PubMed |
| Serum total triglyceride levels | A | β 0.027 | 8E-11 | PubMed |
Sources
- dbSNP: rs6968865 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies