Genetic variant
rs6921438
rs6921438 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6921438 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A common variant highly associated with plasma VEGFA levels also contributes to the variation of both LDL-C and HDL-C
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6921438, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6921438
- Position
- chr6:43957870
Genome-wide association studies (17)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Vascular endothelial growth factor levels | A | OR 0.64 | 2E-1449 | PubMed |
| Isoform L-VEGF165 levels | A | OR 0.81 | 8E-1239 | PubMed |
| Vascular endothelial growth factor A, isoform 121 levels | A | OR 0.81 | 6E-1168 | PubMed |
| Vascular endothelial growth factor levels | A | OR 0.44 | 2E-389 | PubMed |
| Vascular endothelial growth factor A levels | A | OR 0.5 | 1E-359 | PubMed |
| Vascular endothelial growth factor A levels | A | OR 0.43 | 4E-323 | PubMed |
| Inflammatory biomarkers (multivariate analysis) | — | — | 3E-296 | PubMed |
| Vascular endothelial growth factor A, isoform 121 levels (VEGFA.14032.2.3) | A | OR 0.7 | 2E-234 | PubMed |
| Vascular endothelial growth factor levels | G | OR 0.49 | 2E-171 | PubMed |
| Vascular endothelial growth factor receptor 1 levels | A | OR 0.26 | 3E-94 | PubMed |
| Vascular endothelial growth factor A levels (VEGFA.2597.8.3) | A | OR 0.42 | 8E-71 | PubMed |
| Vascular endothelial growth factor A, isoform 121 levels | A | OR 0.44 | 1E-58 | PubMed |
| Vascular endothelial growth factor B levels | A | OR 0.16 | 5E-32 | PubMed |
| Vascular endothelial growth factor A, isoform 121 level in Chronic kidney disease with hypertension and no diabetes (4867_15) | A | OR 0.62 | 3E-24 | PubMed |
| Vascular endothelial growth factor A, isoform 121 level in Chronic kidney disease with hypertension and no diabetes (14032_2) | A | OR 0.62 | 3E-24 | PubMed |
| Serum levels of protein VEGFB | A | OR 0.18 | 3E-21 | PubMed |
| Vascular endothelial growth factor A levels | A | OR 0.22 | 2E-16 | PubMed |
Sources
- dbSNP: rs6921438 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies