Genetic variant
rs6894249
rs6894249 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6894249 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Disease-associated SNPs From non-coding regions in juvenile idiopathic arthritis are located within or adjacent to functional genomic elements of human neutrophils and CD4 T Cells
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6894249, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6894249
- Position
- chr5:132461855
Genome-wide association studies (15)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Asthma or chronic rhinosinusitis | — | OR 0.93 | 2E-39 | PubMed |
| Tryptophan betaine levels | G | OR 0.18 | 7E-33 | PubMed |
| Serum metabolite levels | A | OR 0.23 | 9E-26 | PubMed |
| Total cholesterol levels | — | — | 3E-22 | PubMed |
| ACY3 protein levels | G | β 0.049 | 1E-18 | PubMed |
| Total cholesterol levels | G | β 0.014 | 2E-16 | PubMed |
| Aspartate aminotransferase levels | A | OR 7.14 | 1E-12 | PubMed |
| SULT2A1 protein levels | G | β 0.039 | 7E-12 | PubMed |
| Asthma | G | β 0.09 | 2E-11 | PubMed |
| Psoriasis | A | β 0.066 | 3E-10 | PubMed |
| Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) | — | OR 1.32 | 1E-9 | PubMed |
| LDL cholesterol | A | β 0.015 | 6E-9 | PubMed |
| Vasculitis (pleiotropy) | — | — | 8E-9 | PubMed |
| Body fat percentage (adjusted for testosterone and SHBG) | — | OR 0.12 | 1E-8 | PubMed |
| Eczema | — | — | 3E-8 | PubMed |
Sources
- dbSNP: rs6894249 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies