Genetic variant
rs6859
rs6859 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6859 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
The risk allele associated with late-onset Alzheimer's disease is A. [GWAS:Alzheimer's disease]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6859, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6859
- Position
- chr19:44878777
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Apolipoprotein B levels | G | OR 0.12 | 2E-533 | PubMed |
| Low density lipoprotein cholesterol levels | G | β 0.096 | 4E-347 | PubMed |
| Total cholesterol levels | G | β 0.079 | 3E-236 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | — | — | 1E-155 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | A | OR 26.32 | 1E-152 | PubMed |
| Alzheimer's disease (MTAG) | A | β 0.054 | 5E-135 | PubMed |
| C-reactive protein levels | G | β 0.055 | 6E-115 | PubMed |
| Alzheimer's disease (MTAG) | A | β 0.041 | 3E-97 | PubMed |
| Alzheimer's disease (MTAG) | A | β 0.039 | 1E-91 | PubMed |
| Alzheimer's disease (MTAG) | A | β 0.036 | 5E-89 | PubMed |
| C-reactive protein levels (MTAG) | A | β 0.037 | 1E-75 | PubMed |
| Family history of Alzheimer's disease | — | — | 6E-75 | PubMed |
| Alzheimer's disease (onset between ages 58 and 79) | A | OR 1.44 | 7E-39 | PubMed |
| LDL cholesterol levels | A | OR 2.57 | 8E-37 | PubMed |
| Linoleic acid levels | A | — | 7E-36 | PubMed |
| Omega-6 fatty acid levels | A | — | 4E-35 | PubMed |
| APOE protein levels | — | OR 0.39 | 3E-34 | PubMed |
| Apolipoprotein A1 levels | G | β 0.03 | 2E-33 | PubMed |
| LDL cholesterol levels x long total sleep time interaction (2df test) | — | OR 2.23 | 8E-30 | PubMed |
| Alzheimer's disease | A | OR 1.37 | 5E-27 | PubMed |
Sources
- dbSNP: rs6859 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies