Genetic variant
rs6843082
rs6843082 is a single-letter difference in human DNA, on chromosome 4. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6843082 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6843082, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6843082
- Position
- chr4:110796911
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Atrial fibrillation | G | OR 1.45 | 2E-1141 | PubMed |
| Atrial fibrillation | G | OR 1.47 | 4E-427 | PubMed |
| Atrial fibrillation | A | OR 0.34 | 5E-305 | PubMed |
| Atrial fibrillation | G | OR 1.45 | 3E-155 | PubMed |
| Cardiac dysrhythmias (PheCode 427) | G | OR 0.13 | 3E-130 | PubMed |
| Atrial fibrillation | G | OR 1.84 | 1E-126 | PubMed |
| Atrial fibrillation and flutter (PheCode 427.2) | — | — | 2E-75 | PubMed |
| Atrial fibrillation (PheCode 427.21) | — | — | 7E-70 | PubMed |
| Atrial fibrillation | G | OR 1.6 | 2E-62 | PubMed |
| Incident atrial fibrillation | G | OR 1.38 | 8E-57 | PubMed |
| PT international normalized ratio (INR, mean, inv-norm transformed) | G | β 0.056 | 1E-54 | PubMed |
| prothrombin time (PT, mean, inv-norm transformed) | G | β 0.078 | 2E-36 | PubMed |
| prothrombin time (PT, maximum, inv-norm transformed) | G | β 0.074 | 1E-33 | PubMed |
| Atrial fibrillation (PheCode 427.21) | G | OR 0.2 | 3E-33 | PubMed |
| Atrial fibrillation | G | OR 2.03 | 3E-28 | PubMed |
| heart rate (HR, maximum, inv-normal transformed) | G | β 0.029 | 7E-21 | PubMed |
| prothrombin time (PT, minimum, inv-norm transformed) | G | β 0.058 | 2E-20 | PubMed |
| Stroke (ischemic) | G | OR 1.36 | 3E-16 | PubMed |
| Encounter for long-term (current) use of anticoagulants (PheCode 286.2) | G | OR 0.22 | 9E-14 | PubMed |
| Abnormal coagulation profile (PheCode 286.9) | G | OR 0.17 | 1E-13 | PubMed |
Sources
- dbSNP: rs6843082 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies