Genetic variant
rs6801957
rs6801957 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6801957 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6801957, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6801957
- Position
- chr3:38725824
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| PR interval | T | OR 3.49 | 6E-634 | PubMed |
| Brugada syndrome | C | β 0.41 | 6E-217 | PubMed |
| Brugada syndrome | T | OR 2.49 | 1E-180 | PubMed |
| Electrocardiogram morphology (amplitude at temporal datapoints) | T | OR 0.14 | 3E-133 | PubMed |
| PR interval | C | OR 4.06 | 5E-107 | PubMed |
| ECG latent space | — | — | 6E-107 | PubMed |
| ECG cardiac MRI latent space | — | — | 7E-107 | PubMed |
| Atrial fibrillation | T | β 0.071 | 1E-96 | PubMed |
| Atrial fibrillation | T | β 0.07 | 1E-87 | PubMed |
| PR interval | — | OR 3.88 | 1E-59 | PubMed |
| PR interval | T | OR 3.9 | 1E-55 | PubMed |
| Atrial fibrillation (PheCode 427.21) | T | β 0.085 | 4E-53 | PubMed |
| Atrial fibrillation and flutter (PheCode 427.2) | T | β 0.081 | 5E-50 | PubMed |
| PR segment duration | T | OR 2.94 | 7E-41 | PubMed |
| QRS duration | — | OR 0.77 | 7E-40 | PubMed |
| Atrial fibrillation (PheCode 427.21) | T | β 0.084 | 8E-36 | PubMed |
| heart rate (HR, mean, inv-normal transformed) | T | β 0.032 | 7E-34 | PubMed |
| Atrial fibrillation and flutter (PheCode 427.2) | T | β 0.08 | 3E-33 | PubMed |
| QRS duration | T | OR 0.73 | 2E-30 | PubMed |
| QRS duration | T | OR 0.77 | 1E-28 | PubMed |
Sources
- dbSNP: rs6801957 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies