Genetic variant
rs676210
rs676210 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs676210 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs676210, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs676210
- Position
- chr2:21008652
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Phospholipids to Total Lipids in IDL percentage | A | OR 0.13 | 2E-622 | PubMed |
| Triglycerides in small VLDL | A | OR 0.12 | 3E-506 | PubMed |
| Cholesteryl Esters to Total Lipids in IDL percentage | A | OR 0.11 | 6E-477 | PubMed |
| Free Cholesterol to Total Lipids in Large LDL percentage | A | β 0.1 | 3E-442 | PubMed |
| Cholesterol to Total Lipids in IDL percentage | A | β 0.1 | 1E-420 | PubMed |
| Concentration of small VLDL particles | A | OR 0.11 | 2E-401 | PubMed |
| Triglyceride levels | — | — | 4E-398 | PubMed |
| Triglycerides to Total Lipids in Small HDL percentage | A | β 0.1 | 2E-389 | PubMed |
| Triglyceride to phosphoglyceride ratio | A | β 0.1 | 2E-389 | PubMed |
| Cholesteryl Esters to Total Lipids in Medium LDL percentage | A | OR 0.11 | 8E-388 | PubMed |
| Triglycerides in very small VLDL | A | β 0.1 | 3E-383 | PubMed |
| Free Cholesterol to Total Lipids in Medium LDL percentage | A | β 0.1 | 7E-382 | PubMed |
| Total lipids in small VLDL | A | β 0.1 | 1E-364 | PubMed |
| Cholesteryl Esters to Total Lipids in Large LDL percentage | A | β 0.1 | 3E-359 | PubMed |
| Cholesteryl Esters in Large VLDL | A | β 0.1 | 7E-353 | PubMed |
| Cholesterol in Large VLDL | A | β 0.1 | 6E-341 | PubMed |
| Triglycerides in medium VLDL | A | β 0.1 | 3E-339 | PubMed |
| Phospholipids in large VLDL | A | β 0.09 | 5E-326 | PubMed |
| Triglycerides to Total Lipids in Medium HDL percentage | A | β 0.09 | 8E-323 | PubMed |
| Phospholipids to Total Lipids in Medium LDL percentage | A | β 0.1 | 1E-316 | PubMed |
Sources
- dbSNP: rs676210 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies