Genetic variant
rs6740847
rs6740847 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6740847 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
LPAR1 and ITGA4 regulate peripheral blood monocyte counts
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6740847, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6740847
- Position
- chr2:181443625
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| monocyte (fraction, minimum, inv-norm transformed) | A | OR 0.12 | 1E-323 | PubMed |
| monocyte (fraction, mean, inv-norm transformed) | A | OR 0.17 | 1E-323 | PubMed |
| monocyte (fraction, maximum, inv-norm transformed) | A | OR 0.13 | 1E-323 | PubMed |
| monocyte (absolute count, minimum, inv-norm transformed) | A | OR 0.14 | 1E-323 | PubMed |
| monocyte (absolute count, mean, inv-norm transformed) | A | OR 0.17 | 1E-323 | PubMed |
| monocyte (absolute count, maximum, inv-norm transformed) | A | OR 0.13 | 1E-323 | PubMed |
| monocyte (fraction, minimum, inv-norm transformed) | A | OR 0.14 | 1E-323 | PubMed |
| monocyte (fraction, mean, inv-norm transformed) | A | OR 0.2 | 1E-323 | PubMed |
| monocyte (fraction, maximum, inv-norm transformed) | A | OR 0.14 | 1E-323 | PubMed |
| monocyte (absolute count, minimum, inv-norm transformed) | A | OR 0.17 | 1E-323 | PubMed |
| monocyte (absolute count, mean, inv-norm transformed) | A | OR 0.21 | 1E-323 | PubMed |
| monocyte (absolute count, maximum, inv-norm transformed) | A | OR 0.15 | 1E-323 | PubMed |
| Neutrophil count | G | β 0.022 | 4E-29 | PubMed |
| Myeloid white cell count | G | β 0.04 | 1E-27 | PubMed |
| White blood cell count | G | β 0.037 | 4E-25 | PubMed |
| eosinophil (absolute count, mean, inv-norm transformed) | A | β 0.032 | 3E-23 | PubMed |
| Inflammatory bowel disease | A | OR 1.1 | 1E-13 | PubMed |
| Immature granulocyte count | G | β 0.053 | 5E-13 | PubMed |
| Sum neutrophil eosinophil counts | G | β 0.026 | 9E-13 | PubMed |
| Granulocyte count | G | β 0.026 | 1E-12 | PubMed |
Sources
- dbSNP: rs6740847 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies