RS671 ALDH2
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What This Variant Does
"rs671 is a classic SNP, well known in a sense through the phenomena known as the 'alcohol flush', al...
Associated Conditions
Alcohol sensitivity
acute
Alcohol dependence
Susceptibility to hangover
ESOPHAGEAL CANCER
ALCOHOL-RELATED
SUSCEPTIBILITY TO
AMED syndrome
digenic
ethanol response - Toxicity
ALDH2-related disorder
NITROGLYCERIN
POOR RESPONSE TO
Alcohol sensitivity
acute
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Alcohol consumption (drinkers vs non-drinkers) | — | OR: 1.82 | 1E-4740 | PubMed |
| Daily alcohol intake | A | OR: 0.59 | 2E-2658 | PubMed |
| Alcohol consumption (drinks per week) | — | OR: 0.43 | 1E-450 | PubMed |
| Gamma glutamyl transpeptidase | A | OR: 0.17 | 4E-411 | PubMed |
| Gamma glutamyl transpeptidase | A | OR: 0.17 | 7E-411 | PubMed |
| Drinking behavior | — | OR: 6.25 | 4E-211 | PubMed |
| High-density lipoprotein levels | A | β: 0.085 | 1E-207 | PubMed |
| Aspartate aminotransferase levels | A | OR: 0.16 | 2E-171 | PubMed |
| Coffee consumption | — | OR: 0.35 | 4E-153 | PubMed |
| Diastolic blood pressure | A | β: 0.059 | 6E-117 | PubMed |
| Alanine aminotransferase levels | A | OR: 0.12 | 8E-112 | PubMed |
| Myocardial infarction | A | OR: 0.33 | 1E-101 | PubMed |
| Myocardial infarction | A | OR: 0.33 | 1E-101 | PubMed |
| Systolic blood pressure | A | β: 0.053 | 9E-99 | PubMed |
| HDL cholesterol levels | A | OR: 0.12 | 8E-96 | PubMed |
| Alcohol consumption | A | OR: 1.39 | 8E-92 | PubMed |
| Fasting blood glucose | A | OR: 0.12 | 1E-91 | PubMed |
| Mean corpuscular volume | A | β: 0.085 | 2E-91 | PubMed |
| Heavy drinking | A | OR: 1.16 | 2E-83 | PubMed |
| Alcohol consumption (drinkers vs non-drinkers) | — | OR: 2.5 | 2E-72 | PubMed |
ClinVar Assertions (1)
NM_000690.4(ALDH2):c.1510G>A (p.Glu504Lys)
Population Frequencies
gnomAD ALL
0.7%
1kG AFR
0.2%
1kG ALL
96.4%
1kG AMR
99.7%
1kG EAS
17.4%
1kG EUR
100%
1kG SAS
100%