Genetic variant
rs6601299
rs6601299 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6601299 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6601299, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6601299
- Position
- chr8:9327181
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| 3-Hydroxybutyrate levels | C | β 0.06 | 1E-63 | PubMed |
| High density lipoprotein cholesterol levels | T | β 0.079 | 3E-44 | PubMed |
| High density lipoprotein cholesterol levels | C | β 0.09 | 7E-36 | PubMed |
| Total cholesterol levels | T | OR 0.11 | 2E-23 | PubMed |
| Glycoprotein acetyls levels | T | β 0.067 | 5E-23 | PubMed |
| Cholesteryl ester levels in LDL | T | β 0.061 | 5E-19 | PubMed |
| PON3 protein levels | C | β 0.074 | 3E-18 | PubMed |
| High density lipoprotein cholesterol levels | — | OR 1.3 | 7E-18 | PubMed |
| Total lipid levels in LDL | T | β 0.058 | 2E-17 | PubMed |
| Clinical LDL cholesterol levels | T | β 0.058 | 3E-17 | PubMed |
| Cholesterol levels in medium LDL | T | β 0.057 | 1E-16 | PubMed |
| Phospholipid levels in LDL | T | β 0.056 | 2E-16 | PubMed |
| LDL cholesterol levels x long total sleep time interaction (2df test) | — | OR 1.58 | 3E-16 | PubMed |
| Total fatty acid levels | T | — | 3E-16 | PubMed |
| Total lipid levels in medium LDL | T | β 0.055 | 1E-15 | PubMed |
| Cholesteryl ester levels in medium LDL | T | β 0.055 | 1E-15 | PubMed |
| Low density lipoprotein cholesterol levels | T | β 0.057 | 1E-15 | PubMed |
| Phospholipid levels in medium LDL | T | β 0.055 | 2E-15 | PubMed |
| Total cholesterol minus HDL-C levels | T | β 0.054 | 2E-15 | PubMed |
| 3-hydroxybutyrate (bhba) levels | C | OR 0.19 | 5E-15 | PubMed |
Sources
- dbSNP: rs6601299 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies