Genetic variant
rs653178
rs653178 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs653178 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
This SNP, rs653178, is basically a proxy (r<
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs653178, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs653178
- Position
- chr12:111569952
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Lymphocyte count | T | — | 2E-492 | PubMed |
| Eosinophill percentage (UKB data field 30210) | T | β 0.073 | 6E-304 | PubMed |
| Cystatin C plasma levels | — | — | 3E-239 | PubMed |
| Eosinophil count | T | OR 0.1 | 1E-180 | PubMed |
| Cystatin C levels | T | β 0.068 | 3E-174 | PubMed |
| Sum eosinophil basophil counts | T | β 0.098 | 7E-167 | PubMed |
| Diastolic blood pressure (MTAG) | C | β 0.047 | 4E-164 | PubMed |
| Eosinophil percentage of granulocytes | T | β 0.085 | 4E-126 | PubMed |
| Eosinophil percentage of white cells | T | β 0.083 | 3E-120 | PubMed |
| Neutrophils and lymphocytes in blood (confirmatory factor analysis Factor 35) | — | — | 3E-119 | PubMed |
| Diastolic blood pressure | T | OR 0.48 | 6E-115 | PubMed |
| Neutrophil percentage of white cells | T | β 0.05 | 8E-111 | PubMed |
| Neutrophil percentage of granulocytes | T | β 0.079 | 5E-108 | PubMed |
| Neutrophill percentage (UKB data field 30200) | T | β 0.044 | 3E-107 | PubMed |
| Total cholesterol levels | — | — | 9E-84 | PubMed |
| Red blood cell count | T | β 0.041 | 5E-78 | PubMed |
| Lymphocyte percentage of white cells | T | β 0.041 | 2E-75 | PubMed |
| Lymphocyte percentage (UKB data field 30180) | T | β 0.035 | 2E-70 | PubMed |
| Hemoglobin concentration | C | β 0.057 | 6E-67 | PubMed |
| Hemoglobin concentration | C | β 0.064 | 3E-66 | PubMed |
Sources
- dbSNP: rs653178 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies