Genetic variant
rs651007
rs651007 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs651007 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs651007, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs651007
- Position
- chr9:133278431
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| E-selectin levels | T | OR 0.94 | 1E-96 | PubMed |
| E-selectin levels | T | OR 17.23 | 2E-82 | PubMed |
| Low density lipoprotein cholesterol levels | C | OR 0.15 | 3E-59 | PubMed |
| Serum alkaline phosphatase levels | A | β 0.079 | 1E-56 | PubMed |
| Total cholesterol levels | C | OR 0.12 | 3E-48 | PubMed |
| Insulin receptor levels | T | OR 0.7 | 4E-44 | PubMed |
| Vascular endothelial growth factor receptor 3 levels | T | OR 0.59 | 1E-31 | PubMed |
| Platelet glycoprotein 4 levels | T | OR 0.54 | 1E-29 | PubMed |
| PIK3IP1/TNFRSF1A protein level ratio | — | β 0.095 | 3E-29 | PubMed |
| Endoglin levels | T | OR 0.54 | 6E-26 | PubMed |
| End-stage coagulation | C | OR 0.46 | 2E-25 | PubMed |
| ADpSGEGDFXAEGGGVR levels | T | β 0.065 | 6E-20 | PubMed |
| Hepatocyte growth factor receptor levels | T | OR 0.44 | 3E-19 | PubMed |
| Coronary artery disease | T | OR 1.06 | 1E-18 | PubMed |
| Hematocrit | — | — | 7E-17 | PubMed |
| Serum metabolite levels | — | β 0.067 | 1E-15 | PubMed |
| Intercellular adhesion molecule 2 levels | T | OR 0.4 | 7E-15 | PubMed |
| IL7RA protein level (protein group normalized intensity) | T | OR 0.36 | 2E-13 | PubMed |
| Vascular endothelial growth factor receptor 2 levels | T | OR 0.37 | 3E-13 | PubMed |
| P-selectin levels | T | OR 0.37 | 7E-13 | PubMed |
Sources
- dbSNP: rs651007 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies