Genetic variant
rs646776
rs646776 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs646776 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs599839 and rs4970834 explain about 1%
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs646776, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs646776
- Position
- chr1:109275908
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Low density lipoprotein cholesterol levels | C | OR 0.18 | 5E-242 | PubMed |
| Cholesterol esters in small LDL | T | OR 0.15 | 1E-219 | PubMed |
| Cholesterol esters in medium LDL | T | OR 0.15 | 3E-217 | PubMed |
| Total cholesterol in medium LDL | T | OR 0.15 | 2E-215 | PubMed |
| Total Cholesterol in small LDL | T | OR 0.15 | 1E-214 | PubMed |
| Total cholesterol levels in LDL | T | OR 0.15 | 2E-212 | PubMed |
| Granulins levels (GRN.4992.49.1) | T | OR 0.83 | 8E-211 | PubMed |
| Cholesteryl esters to total lipids ratio in small LDL | T | OR 0.14 | 1E-207 | PubMed |
| Total cholesterol in large LDL | T | OR 0.14 | 1E-206 | PubMed |
| Free cholesterol in large LDL | T | OR 0.14 | 2E-206 | PubMed |
| Total lipid levels in medium LDL | T | OR 0.14 | 8E-206 | PubMed |
| Cholesterol esters in large LDL | T | OR 0.14 | 8E-205 | PubMed |
| Concentration of medium LDL particles | T | OR 0.14 | 5E-203 | PubMed |
| Total lipids in large LDL | T | OR 0.14 | 9E-201 | PubMed |
| Free cholesterol in medium LDL | T | OR 0.14 | 1E-198 | PubMed |
| Total lipids in small LDL | T | OR 0.14 | 9E-198 | PubMed |
| Cholesteryl esters to total lipids ratio in medium LDL | T | OR 0.14 | 2E-197 | PubMed |
| Concentration of large LDL particles | T | OR 0.14 | 7E-197 | PubMed |
| Concentration of small LDL particles | T | OR 0.14 | 1E-193 | PubMed |
| Free cholesterol in IDL | T | OR 0.14 | 9E-193 | PubMed |
Sources
- dbSNP: rs646776 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies