Genetic variant
rs6445035
rs6445035 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6445035 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6445035, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6445035
- Position
- chr3:165762312
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Platelet-activating factor acetylhydrolase levels | A | OR 0.41 | 4E-149 | PubMed |
| BCHE protein levels | — | OR 0.63 | 3E-54 | PubMed |
| Calcium-activated potassium channel subunit beta-3 levels | A | OR 0.21 | 1E-37 | PubMed |
| N-acetylneuraminate lyase levels | A | OR 0.17 | 1E-25 | PubMed |
| Serum levels of protein APOC3 | A | OR 0.25 | 1E-24 | PubMed |
| Serum levels of protein NXPH2 | A | OR 0.24 | 2E-24 | PubMed |
| Probable ATP-dependent RNA helicase DDX46 levels | A | OR 0.16 | 1E-23 | PubMed |
| T-complex protein 11 homolog levels | A | OR 0.16 | 6E-23 | PubMed |
| Tachykinin-4 levels | A | OR 0.16 | 2E-22 | PubMed |
| Rho GTPase-activating protein 1 levels | A | OR 0.15 | 3E-21 | PubMed |
| Protein NDRG4 levels | A | OR 0.15 | 1E-19 | PubMed |
| Dual specificity mitogen-activated protein kinase kinase 1 levels | A | OR 0.15 | 3E-19 | PubMed |
| Leucine-rich repeat-containing protein 59 levels | A | OR 0.13 | 5E-17 | PubMed |
| Catechol O-methyltransferase levels | A | OR 0.14 | 7E-17 | PubMed |
| Aspirin hydrolysis (plasma) | A | — | 9E-17 | PubMed |
| Tumor necrosis factor receptor superfamily member 4 levels | A | OR 0.13 | 9E-15 | PubMed |
| Ras-related protein Rab-27B levels | A | OR 0.12 | 2E-13 | PubMed |
| Leukocyte antigen CD37 levels | A | OR 0.12 | 8E-13 | PubMed |
| Serum levels of protein COPS7B | A | OR 0.17 | 1E-12 | PubMed |
Sources
- dbSNP: rs6445035 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies