Genetic variant
rs62048402
rs62048402 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs62048402 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs62048402, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs62048402
- Position
- chr16:53769311
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Weight (minimum, inv-normal transformed) | G | OR 0.12 | 6E-241 | PubMed |
| Blood urea nitrogen (BUN, mean, inv-norm transformed) | G | β 0.048 | 5E-90 | PubMed |
| Weight | A | β 0.071 | 4E-75 | PubMed |
| Edema (PheCode 782.3) | G | β 0.09 | 1E-53 | PubMed |
| Obstructive sleep apnea | — | OR 1.08 | 6E-52 | PubMed |
| Blood urea nitrogen (BUN, maximum, inv-norm transformed) | G | β 0.038 | 2E-49 | PubMed |
| Hypertension (PheCode 401) | G | β 0.085 | 2E-42 | PubMed |
| Polyneuropathy in diabetes (PheCode 250.6) | G | OR 0.13 | 4E-38 | PubMed |
| Chronic venous insufficiency [CVI] (PheCode 456) | G | OR 0.12 | 7E-38 | PubMed |
| Drinks per week | A | β 0.011 | 1E-37 | PubMed |
| Chronic ulcer of leg or foot (PheCode 707.2) | G | OR 0.13 | 1E-33 | PubMed |
| Chronic ulcer of skin (PheCode 707) | G | OR 0.11 | 5E-33 | PubMed |
| Weight (mean, inv-normal transformed) | G | β 0.087 | 3E-30 | PubMed |
| Cellulitis and abscess of leg, except foot (PheCode 681.5) | G | OR 0.11 | 3E-25 | PubMed |
| Congestive heart failure; nonhypertensive (PheCode 428) | G | β 0.07 | 4E-24 | PubMed |
| Breast cancer | A | β 0.062 | 4E-23 | PubMed |
| Overweight, obesity and other hyperalimentation (PheCode 278) | G | OR 0.14 | 2E-22 | PubMed |
| Medication use (diuretics) | A | β 0.065 | 3E-21 | PubMed |
| hemoglobin (mean, inv-norm transformed) | G | β 0.024 | 2E-20 | PubMed |
| Atrial fibrillation (MTAG) | A | OR 9.2 | 3E-20 | PubMed |
Sources
- dbSNP: rs62048402 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies