Genetic variant
rs61839660
rs61839660 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs61839660 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs61839660, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs61839660
- Position
- chr10:6052734
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Atopic/contact dermatitis due to other or unspecified (PheCode 939) | C | OR 0.14 | 3E-45 | PubMed |
| Atopic/contact dermatitis due to other or unspecified (PheCode 939) | C | OR 0.14 | 2E-42 | PubMed |
| Type 1 diabetes | C | OR 1.61 | 3E-39 | PubMed |
| Eczema | — | — | 4E-38 | PubMed |
| Lymphocyte percentage (UKB data field 30180) | T | β 0.041 | 2E-36 | PubMed |
| Lymphocyte count (UKB data field 30120) | T | β 0.04 | 4E-35 | PubMed |
| Hay fever and/or eczema | T | OR 1.12 | 1E-32 | PubMed |
| Type 1 diabetes | T | OR 0.69 | 3E-32 | PubMed |
| Lymphocyte percentage of white cells | T | β 0.042 | 5E-29 | PubMed |
| Allergic disease (asthma, hay fever or eczema) | T | OR 1.1 | 3E-28 | PubMed |
| CD25++ CD45RA- CD4 not regulatory T cell %CD4+ T cell | T | OR 0.61 | 3E-28 | PubMed |
| CD25 on CD45RA- CD4 not regulatory T cell | T | OR 0.61 | 7E-28 | PubMed |
| CD25++ CD4+ T cell %CD4+ T cell | T | OR 0.59 | 2E-26 | PubMed |
| Lymphocyte count | T | β 0.042 | 2E-25 | PubMed |
| CD25++ CD45RA- CD4 not regulatory T cell %T cell | T | OR 0.58 | 5E-25 | PubMed |
| Lymphocyte count | T | β 0.038 | 3E-23 | PubMed |
| CD25++ CD45RA- CD4 not regulatory T cell Absolute Count | T | OR 0.55 | 2E-22 | PubMed |
| Neutrophil-to-lymphocyte ratio | C | — | 1E-21 | PubMed |
| Skin condition (ex. Eczema, Psoriasis) | C | OR 0.13 | 2E-21 | PubMed |
| lymphocyte (absolute count, maximum, inv-norm transformed) | C | β 0.052 | 3E-21 | PubMed |
Sources
- dbSNP: rs61839660 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies