Genetic variant
rs613872
rs613872 is a single-letter difference in human DNA, on chromosome 18. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs613872 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs613872 is an intronic SNP in the transcription factor 4 TCF4 gene on ch18q21.2. This GWAS study re...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs613872, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs613872
- Position
- chr18:55543071
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Central corneal thickness (MTAG) | T | OR 2.88 | 2E-21 | PubMed |
| Educational attainment (MTAG) | T | β 0.016 | 9E-20 | PubMed |
| Fuchs's corneal dystrophy | G | OR 5.47 | 1E-18 | PubMed |
| Highest math class taken (MTAG) | T | β 0.019 | 1E-18 | PubMed |
| Impedance of whole body (UKB data field 23106) | T | β 0.016 | 2E-18 | PubMed |
| Educational attainment (years of education) | T | β 0.016 | 2E-18 | PubMed |
| SIOPS occupational score (MTAG) | — | β 0.017 | 4E-18 | PubMed |
| CAMSIS occupational score (MTAG) | — | β 0.019 | 7E-18 | PubMed |
| ISEI occupational score (MTAG) | — | β 0.018 | 7E-18 | PubMed |
| white blood cell count (WBC, mean, inv-norm transformed) | G | β 0.032 | 1E-17 | PubMed |
| Loneliness (MTAG) | G | β 0.023 | 4E-17 | PubMed |
| BMI and adiposity (confirmatory factor analysis Factor 7) | — | — | 6E-16 | PubMed |
| Mood instability | — | β 0.012 | 1E-14 | PubMed |
| Loneliness | G | β 0.008 | 5E-14 | PubMed |
| Self-reported math ability (MTAG) | T | β 0.018 | 8E-14 | PubMed |
| monocyte (absolute count, mean, inv-norm transformed) | G | β 0.032 | 2E-13 | PubMed |
| Educational attainment (years of education) | — | — | 1E-12 | PubMed |
| Educational attainment | — | — | 2E-12 | PubMed |
| Experiencing mood swings | T | OR 7.06 | 2E-12 | PubMed |
| Monocyte count | T | β 0.017 | 3E-12 | PubMed |
Sources
- dbSNP: rs613872 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies