Genetic variant
rs6136
rs6136 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6136 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
cardiovascular risk [OMIM:?] [GWAS:Soluble levels of adhesion molecules]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6136, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6136
- Position
- chr1:169594713
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| SELP/VSIR protein level ratio | — | OR 0.59 | 7E-662 | PubMed |
| GP1BA/SELP protein level ratio | — | OR 0.53 | 3E-541 | PubMed |
| CD46/SELP protein level ratio | — | OR 0.52 | 1E-532 | PubMed |
| SDC4/SELP protein level ratio | — | OR 0.48 | 4E-437 | PubMed |
| ITGB1/SELP protein level ratio | — | OR 0.44 | 1E-385 | PubMed |
| Blood protein levels | T | OR 1.04 | 2E-184 | PubMed |
| P-selectin levels (SELP.4154.57.2) | G | OR 0.81 | 3E-105 | PubMed |
| P-selectin levels | G | OR 0.7 | 6E-90 | PubMed |
| Blood protein levels | G | OR 0.61 | 4E-87 | PubMed |
| Soluble levels of adhesion molecules | T | OR 22.6 | 4E-61 | PubMed |
| P-selectin levels | G | OR 0.24 | 3E-54 | PubMed |
| P-selectin levels | — | OR 0.79 | 7E-54 | PubMed |
| P-selectin levels | T | OR 0.3 | 7E-53 | PubMed |
| P-selectin levels | G | OR 0.77 | 1E-25 | PubMed |
| P-selectin levels | G | OR 0.64 | 9E-24 | PubMed |
| SELP protein levels | — | OR 0.31 | 2E-9 | PubMed |
Sources
- dbSNP: rs6136 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies