Genetic variant

rs6065904

rs6065904 is a single-letter difference in human DNA, on chromosome 20. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6065904 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6065904, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs6065904
Position
chr20:45906012

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Phospholipid levels in very large HDL G OR 0.2 3E-417 PubMed
Total lipid levels in very large HDL G OR 0.19 3E-405 PubMed
Free cholesterol levels in very large HDL G OR 0.2 1E-399 PubMed
Free cholesterol to total lipids ratio in large HDL G OR 0.2 2E-393 PubMed
Cholesterol levels in very large HDL G OR 0.19 2E-372 PubMed
Phospholipids to total lipids ratio in very large HDL G OR 0.19 1E-362 PubMed
Concentration of very large HDL particles G OR 0.18 4E-356 PubMed
Cholesteryl ester levels in very large HDL G OR 0.18 4E-355 PubMed
Average diameter for HDL particles G OR 0.18 2E-339 PubMed
Free Cholesterol in HDL A OR 0.1 2E-211 PubMed
Cholesterol in very large HDL (UKB data field 23554) A OR 0.18 1E-200 PubMed
Phospholipids in very large HDL (UKB data field 23553) A OR 0.19 1E-200 PubMed
Free cholesterol in large HDL (UKB data field 23563) A OR 0.15 1E-200 PubMed
Free cholesterol in very large HDL (UKB data field 23556) A OR 0.2 1E-200 PubMed
Cholesteryl esters in very large HDL (UKB data field 23555) A OR 0.18 1E-200 PubMed
Phospholipids to total lipids in very large HDL percentage (UKB data field 23629) A OR 0.18 1E-200 PubMed
Concentration of very large HDL particles (UKB data field 23551) A OR 0.18 1E-200 PubMed
Average diameter for HDL particles (UKB data field 23433) A OR 0.17 1E-200 PubMed
Total lipids in very large HDL (UKB data field 23552) A OR 0.19 1E-200 PubMed
Free cholesterol to total lipids in large HDL percentage (UKB data field 23637) A OR 0.19 1E-200 PubMed

Sources