Genetic variant

rs603424

rs603424 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs603424 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs603424, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs603424
Position
chr10:100315722

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Mean platelet thrombocyte volume (UKB data field 30100) A β 0.058 4E-154 PubMed
Saturated fatty acids to total fatty acids percentage A β 0.06 1E-126 PubMed
Myristate 14:0-to-myristoleate 14:1n5 ratio A β 0.054 1E-115 PubMed
11-hydroxy-9-octadecenoate, 10-hydroxy-11-octadecenoate levels — OR 0.41 2E-113 PubMed
Mean platelet volume G β 0.057 5E-110 PubMed
Mean platelet volume G — 3E-108 PubMed
Monounsaturated fatty acids to total fatty acids percentage A — 2E-84 PubMed
Eicosanoid 13-oxoODE b levels — OR 0.33 5E-72 PubMed
Mean platelet volume A β 0.054 1E-71 PubMed
Monounsaturated fatty acids to total fatty acids percentage A β 0.04 1E-68 PubMed
Palmitoleic acid levels (253.2182_0.372) — OR 0.27 2E-64 PubMed
Saturated fatty acids to total fatty acids percentage A — 4E-62 PubMed
Ratio of saturated fatty acids to total fatty acids A β 0.087 8E-62 PubMed
Palmitoleic acid levels (253.2182_0.372) x waist circumference interaction (2df) — — 5E-61 PubMed
Monounsaturated fatty acids to total fatty acids percentage A — 8E-61 PubMed
Metabolic traits A OR 0.12 3E-57 PubMed
Leukotriene/HpETE/DiHETE/Prostaglandin/Hepoxilin levels (335.222_0.372) — OR 0.25 1E-56 PubMed
Saturated fatty acid percentage of total fatty acids A β 0.064 3E-54 PubMed
Eicosanoid 5(S) HETrE levels — OR 0.28 2E-50 PubMed
1-(1-enyl-palmitoyl)-2-palmitoleoyl-GPC (P-16:0/16:1) levels A OR 0.2 4E-50 PubMed

Sources