Genetic variant
rs602662
rs602662 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs602662 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs602662, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs602662
- Position
- chr19:48703728
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Human milk oligosaccharide concentration (2'-fucosyllactose) | A | OR 28.15 | 3E-174 | PubMed |
| Human milk oligosaccharide concentration (lacto-N-fucopentaose-I) | A | OR 25.95 | 2E-148 | PubMed |
| Human milk oligosaccharide concentration (Fucose-bound) | A | OR 25.87 | 1E-147 | PubMed |
| Vitamin B12 levels | A | — | 2E-139 | PubMed |
| Human milk oligosaccharide concentration (lacto-N-fucopentaose-II) | A | OR 22.38 | 6E-111 | PubMed |
| Total concentration of 19 human milk oligosaccharides | A | OR 22.24 | 1E-109 | PubMed |
| Human milk oligosaccharide concentration (difucosyllactose) | A | OR 21.7 | 2E-104 | PubMed |
| CPB1/CTRC protein level ratio | — | OR 0.14 | 2E-97 | PubMed |
| CTRC protein levels | A | β 0.094 | 5E-85 | PubMed |
| CPA1/CTRC protein level ratio | — | OR 0.13 | 1E-81 | PubMed |
| Human milk oligosaccharide concentration (fucodisialyllacto-N-hexaose) | A | OR 18.68 | 7E-78 | PubMed |
| PLA2G1B protein levels | A | β 0.091 | 3E-72 | PubMed |
| TNFRSF1A/TNFRSF1B protein level ratio | — | β 0.099 | 7E-47 | PubMed |
| Human milk oligosaccharide concentration (3'-fucosyllactose) | A | OR 13.79 | 3E-43 | PubMed |
| Human milk oligosaccharide concentration (sialyl-lacto-N-tetraose b) | A | OR 12.58 | 3E-36 | PubMed |
| Human milk oligosaccharide concentration (lacto-N-fucopentaose-III) | A | OR 12.08 | 1E-33 | PubMed |
| Human milk oligosaccharide concentration (difucosyllacto-N-tetrose) | A | OR 11.96 | 6E-33 | PubMed |
| Human milk oligosaccharide concentration (lacto-N-tetrose) | A | OR 11.22 | 3E-29 | PubMed |
| Human milk oligosaccharide concentration (difucosyllacto-N-hexaose) | A | OR 11.15 | 7E-29 | PubMed |
| PIK3IP1/TNFRSF1A protein level ratio | — | β 0.074 | 8E-27 | PubMed |
Sources
- dbSNP: rs602662 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies