Genetic variant
rs602633
rs602633 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs602633 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs602633, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs602633
- Position
- chr1:109278889
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Serum levels of protein GRN | T | OR 0.61 | 7E-194 | PubMed |
| Low density lipoprotein cholesterol levels | G | OR 0.19 | 2E-69 | PubMed |
| Coronary artery disease | T | OR 0.11 | 2E-59 | PubMed |
| Coronary artery disease | T | β 0.1 | 4E-58 | PubMed |
| Serum levels of protein CA10 | T | OR 0.33 | 9E-48 | PubMed |
| Concentration of VLDL particles (UKB data field 23428) | T | β 0.074 | 7E-39 | PubMed |
| Serum levels of protein FJX1 | T | OR 0.28 | 1E-37 | PubMed |
| Total lipids in small VLDL (UKB data field 23510) | T | β 0.071 | 1E-35 | PubMed |
| Concentration of small VLDL particles (UKB data field 23509) | T | β 0.07 | 2E-35 | PubMed |
| Coronary artery disease or tissue plasminogen activator levels (pleiotropy) | — | — | 6E-33 | PubMed |
| Coronary artery disease or plasminogen activator inhibitor 1 levels (pleiotropy) | — | — | 9E-33 | PubMed |
| Free cholesterol in VLDL (UKB data field 23420) | T | β 0.067 | 7E-32 | PubMed |
| Serum levels of protein C1QTNF1 | T | OR 0.24 | 2E-29 | PubMed |
| Total cholesterol levels | G | β 0.075 | 1E-27 | PubMed |
| Linoleic acid levels | T | β 0.053 | 2E-27 | PubMed |
| Cholesteryl esters in large VLDL (UKB data field 23499) | T | β 0.062 | 2E-27 | PubMed |
| Cholesteryl esters in very large VLDL (UKB data field 23492) | T | β 0.061 | 2E-27 | PubMed |
| PCDH7 protein levels | G | β 0.076 | 4E-26 | PubMed |
| Triglycerides in very small VLDL | T | β 0.051 | 4E-26 | PubMed |
| Serum levels of protein HFE2 | T | OR 0.23 | 7E-25 | PubMed |
Sources
- dbSNP: rs602633 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies