Genetic variant
rs560887
rs560887 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs560887 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs560887, p = 4 x 10(-7)) *654 normoglycemic subjects, replicated in 9,353 subjects *fasting plasma ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs560887, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs560887
- Position
- chr2:168906638
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Random glucose levels | T | β 0.019 | 1E-751 | PubMed |
| Random glucose levels | T | β 0.019 | 1E-746 | PubMed |
| Glucose levels | C | OR 0.15 | 1E-707 | PubMed |
| Glucose levels | C | β 0.1 | 7E-473 | PubMed |
| Hemoglobin A1c levels | C | OR 0.1 | 2E-379 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | T | OR 0.1 | 5E-297 | PubMed |
| Glucose (fasting status unknown, minimum, inv-norm transformed) | T | β 0.095 | 3E-294 | PubMed |
| Glucose (fasting status unknown, minimum, inv-norm transformed) | T | β 0.091 | 5E-249 | PubMed |
| Fasting blood glucose | C | β 0.075 | 9E-218 | PubMed |
| Fasting glucose | C | β 0.069 | 7E-190 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | T | β 0.095 | 1E-161 | PubMed |
| Glucose levels | T | OR 0.12 | 3E-139 | PubMed |
| Glycated hemoglobin levels | T | β 0.031 | 6E-122 | PubMed |
| Glucose levels | T | OR 0.1 | 8E-119 | PubMed |
| Fasting blood glucose (BMI interaction) | T | β 0 | 2E-113 | PubMed |
| Glucose levels (UKB data field 23470) | T | OR 0.11 | 1E-101 | PubMed |
| Fasting blood glucose | T | β 0.072 | 3E-99 | PubMed |
| Fasting glucose | C | β 0.067 | 8E-92 | PubMed |
| Fasting blood glucose | A | β 0.079 | 4E-87 | PubMed |
| Fasting glucose adjusted for BMI | T | OR 0.17 | 4E-85 | PubMed |
Sources
- dbSNP: rs560887 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies