Genetic variant
rs55853698
rs55853698 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs55853698 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
smoking http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.572.html [OMIM:?]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs55853698, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs55853698
- Position
- chr15:78565597
Genome-wide association studies (9)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Chronic bronchitis (PheCode 496.2) | T | OR 0.13 | 2E-52 | PubMed |
| heart rate (HR, mean, inv-normal transformed) | T | β 0.03 | 6E-26 | PubMed |
| Respiratory failure, insufficiency, arrest (PheCode 509) | T | β 0.084 | 1E-24 | PubMed |
| Solitary pulmonary nodule (PheCode 514.2) | T | β 0.093 | 7E-22 | PubMed |
| Small cell lung carcinoma | G | OR 1.33 | 5E-21 | PubMed |
| Biological Father: Cancer, Lung | T | β 0.092 | 3E-19 | PubMed |
| Post bronchodilator FEV1/FVC ratio | T | β 0.016 | 1E-14 | PubMed |
| Post bronchodilator FEV1 | T | β 0.075 | 7E-14 | PubMed |
| Post bronchodilator FEV1/FVC ratio in COPD | T | β 0.012 | 8E-7 | PubMed |
Sources
- dbSNP: rs55853698 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies